1-cyanopiperazine

Base Information

• Chemical Name: 1-cyanopiperazine
• CAS No.: 34065-01-5
• Molecular Formula: C5H9N3
• Molecular Weight: 111.147
• Mol file: 34065-01-5.mol

Synonyms:piperazine-1-carbonitrile;

Chemical Property of 1-cyanopiperazine

Chemical Property:

• PSA: 39.06000
• LogP: -0.36062

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Cyanopiperazine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-cyanopiperazine

There total 2 articles about 1-cyanopiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + bromocyane (506-68-3) → 1-cyanopiperazine (34065-01-5)

Guidance literature:

In tetrahydrofuran;

Reference yield:

→ 1-cyanopiperazine (34065-01-5)

Guidance literature:

Piperazin, BrCN;

Reference yield: 52.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-cyanopiperazine (34065-01-5) → 4-cyano-piperazine-1-carboxylic acid tert-butyl ester (113534-02-4)

Guidance literature:

In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jm00400a026

upstream raw materials:

piperazine

bromocyane

Downstream raw materials:

4-cyano-piperazine-1-carboxylic acid tert-butyl ester

prazosin

Refernces