3,5-Bis(2-fluorobenzylidene)piperidin-4-one

Base Information

Chemical Name:3,5-Bis(2-fluorobenzylidene)piperidin-4-one
CAS No.:342808-40-6
Molecular Formula:C19H15F2NO
Molecular Weight:311.331
Hs Code.:
European Community (EC) Number:686-985-3
UNII:O5YT36MST0
Nikkaji Number:J2.520.873K
Wikipedia:EF-24
ChEMBL ID:CHEMBL379849
Mol file:342808-40-6.mol

Synonyms:3,5-bis(2-fluorobenzylidene)piperidin-4-one;EF24 compound

Suppliers and Price of 3,5-Bis(2-fluorobenzylidene)piperidin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone
2.5g
$ 1650.00

Sigma-Aldrich
EF-24 ≥98% (HPLC)
25mg
$ 351.00

Sigma-Aldrich
EF-24 ≥98% (HPLC)
5mg
$ 88.20

American Custom Chemicals Corporation
(3E,5E)-3,5-BIS[(2-FLUOROPHENYL)METHYLENE]-4-PIPERIDINONE 95.00%
10MG
$ 1963.50

American Custom Chemicals Corporation
(3E,5E)-3,5-BIS[(2-FLUOROPHENYL)METHYLENE]-4-PIPERIDINONE 95.00%
1MG
$ 750.75

Total 15 raw suppliers

Chemical Property of 3,5-Bis(2-fluorobenzylidene)piperidin-4-one

Chemical Property:

PSA：29.10000
LogP:4.73490
Storage Temp.:?20°C
Solubility.:DMSO: ≥10mg/mL
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:311.11217043
Heavy Atom Count:23
Complexity:458

Purity/Quality:

99% ^*data from raw suppliers

3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn,N
Statements: 22-50
Safety Statements: 61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=CC2=CC=CC=C2F)C(=O)C(=CC3=CC=CC=C3F)CN1
Isomeric SMILES:C\1NC/C(=C\C2=CC=CC=C2F)/C(=O)/C1=C/C3=CC=CC=C3F
Uses 3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone is an analog of curcumin that acts as a kinase inhibitor which mediates anticancer properties.

Technology Process of 3,5-Bis(2-fluorobenzylidene)piperidin-4-one

There total 8 articles about 3,5-Bis(2-fluorobenzylidene)piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 41661-47-6
piperidin-4-one

: 446-52-6
2-Fluorobenzaldehyde

: 342808-40-6
3,5-bis(2-fluorobenzylidene)piperidin-4-one

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃; for 24h;
DOI:10.1007/s00044-017-2056-x

Reference yield:

: 342808-41-7
3,5-bis-(2-fluorobenzylidene)-4-piperidone acetic acid

: 342808-40-6
3,5-bis(2-fluorobenzylidene)piperidin-4-one

Guidance literature:: With potassium carbonate;
DOI:10.1111/j.1747-0285.2011.01271.x

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 446-52-6
2-Fluorobenzaldehyde

: 342808-40-6
3,5-bis(2-fluorobenzylidene)piperidin-4-one

Guidance literature:: 4-piperidone hydrochloride; 2-Fluorobenzaldehyde; With hydrogenchloride; In acetic acid;

With potassium carbonate; In water; acetone;
DOI:10.1016/j.bmc.2013.03.058