Naphthalene, 1-bromo-3-fluoro-

Base Information

• Chemical Name: Naphthalene, 1-bromo-3-fluoro-
• CAS No.: 343-53-3
• Molecular Formula: C10H6BrF
• Molecular Weight: 225.06
• Mol file: 343-53-3.mol

Synonyms:3-Fluor-1-bromnaphthalin;1-Bromo-3-fluoro-naphthalene;1-Brom-3-fluornaphthalin;3-Fluor-1-brom-naphthalin;

Chemical Property of Naphthalene, 1-bromo-3-fluoro-

Chemical Property:

• Melting Point: 31.5 °C (petroleum ether)
• Boiling Point: 84-88 °C(Press: 1 Torr)
• PSA: 0.00000
• Density: 1.563±0.06 g/cm3(Predicted)
• LogP: 3.74140

Purity/Quality:

95% ^*data from raw suppliers

1-Bromo-3-fluoronaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naphthalene, 1-bromo-3-fluoro-

There total 17 articles about Naphthalene, 1-bromo-3-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-bromo-5-fluoro-11-methyl-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5,9-tetraene → 1-bromo-3-fluoro-naphthalene (343-53-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 25 - 40 ℃; for 26h;

Reference yield: 49.0%

4-bromonaphthalene-2-amine (74924-94-0) → 1-bromo-3-fluoro-naphthalene (343-53-3)

Guidance literature:

With hydrofluoride pyridine; sodium nitrite; at 0 - 80 ℃; for 8h; Inert atmosphere;

Reference yield:

3-nitro-1-naphthoic acid (4507-84-0) → 1-bromo-3-fluoro-naphthalene (343-53-3)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂SO₄

2: H₂ / Pd-C / ethanol

3: (i) (diazotization), (ii) aq. HPF₆

4: (i) (heating), (ii) KOH, EtOH

5: NaN₃, H₂SO₄ / CHCl₃

6: (i) NaNO₂, H₂SO₄, (ii) aq. HBr, CuBr

With sodium azide; sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol; chloroform;

DOI:10.1021/ja00978a038

upstream raw materials:

3-fluoronaphthalen-1-ylamine

4-bromonaphthalene-2-amine

3-nitro-1-naphthoic acid

3-fluoronaphthalene-1-carboxylic acid

Downstream raw materials:

3-Fluor-1-o-toluoyl-naphthalin

2-<3-Fluor-naphthyl-(1)-methyl>-benzoesaeure

4-(3-Fluoro-1-naphthoyl)-7-methylhydrindene

2-(3-Fluor-naphthoyl-⁽¹⁾)-benzoesaeure

Refernces

• 1、 -. "KRAS G12D INHIBITORS". Paragraph 0943. . Retrieved 2021/03/05.