74924-94-0

Basic information

• Product Name: 2-Amino-4-bromonaphthalene
• Synonyms: 2-Amino-4-bromonaphthalene;4-BroMonaphthalen-2-aMine;4-Bromo-2-naphthalenamine
• CAS NO: 74924-94-0
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.08122
• Mol File: 74924-94-0.mol

Chemical Properties

• Melting Point: 70-71 °C
• Boiling Point: 360.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.563±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.33±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-4-bromonaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-bromonaphthalene(74924-94-0)
• EPA Substance Registry System: 2-Amino-4-bromonaphthalene(74924-94-0)

Safety Data

• Hazardous Substances Data: 74924-94-0(Hazardous Substances Data)

Upstream product

• 7499-65-2 4-bromo-2-nitronaphthalene 
• 64-19-7 acetic acid 
• 607-23-8 2-nitro-1-naphthylamine 
• 5498-31-7 4-bromo-naphthalen-2-ol 
• 2298-07-9 4-Bromo-1-naphthylamine 
• 7499-73-2 N-(4-bromo-2-nitronaphthalen-1-yl)acetamide 
• 91394-66-0 1-(acetylamino)-4-bromonaphthalene 
• 90767-01-4 4-bromo-2-nitro-1-naphthylamine 

Downstream Products

• 5498-31-7 4-bromo-naphthalen-2-ol 
• 51671-06-8 1-bromo-3-chloronaphthalene 
• 52358-73-3 1,3-dibromonaphthalene 
• 343-53-3 1-bromo-3-fluoro-naphthalene 
• 3109-48-6 2-<3-Fluor-naphthyl-(1)-methyl>-benzoesaeure 
• 3799-79-9 2-(3-Fluor-naphthoyl-⁽¹⁾)-benzoesaeure 
• 1578179-15-3 2-(4-iodonaphthalen-2-ylamino)-5-nitrobenzoic acid 
• 228107-17-3 3-amino-1-phenylnaphthalene 
• 147397-59-9 1-cyano-3-methoxynaphthalene 
• 147397-60-2 3-methoxy-1-naphthoic acid 

Relevant articles and documents

A Chiral Iron Disulfonate Catalyst for the Enantioselective Synthesis of 2-Amino-2′-hydroxy-1,1′-binaphthyls (NOBINs)

A novel type of chiral redox disulfonate iron complex for asymmetric catalysis is reported. The [Fe((Ra)-BINSate)]+(BINSate = 1,1′-binaphthalene-2,2′-disulfonate) complex effectively promotes the enantioselective oxidative cross-coupling between 2-naphthols (1) and 2-aminonaphthalene derivatives (2), affording optically enriched (Ra)-2-amino-2′-hydroxy-1,1′-binaphthyls (NOBINs) with exceptional yields and enantioselective ratios (up to 99% yield and 96:4 er). The [Fe((Ra)-BINSate)]+catalyst was designed as a chiral version of FeCl3with multicoordination sites available for binding the two coupling partners 1 and 2 as well as the oxidant. Our structure-selectivity and activity study, which covered most of the important positions in the NOBIN scaffold, revealed the effect of different substitution patterns on the coupling efficiency and stereoselectivity.

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.