Cefzil

Base Information

• Chemical Name: Cefzil
• CAS No.: 121123-17-9
• Molecular Formula: C₁₈H₁₉N₃O₅S*H₂O
• Molecular Weight: 407.447
• Hs Code.: 29419000
• European Community (EC) Number: 618-870-0,685-390-6
• UNII: 3ADV90MJVU
• Wikipedia: Cefprozil
• Wikidata: Q27256965
• NCI Thesaurus Code: C28917,C77189
• RXCUI: 19552
• Mol file: 121123-17-9.mol

Synonyms:7-(2-amino-2-(4-hydroxyphenyl)acetamido)-3-(propenyl)-3-cephem-4-carboxylic acid monohydrate;7-(2-amino-2-(p-hydroxyphenyl)acetamido)-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;Arzimol;BMY 28100;BMY-28100;Brisoral;cefprozil;cefprozil monohydrate;Cefzil;Procef

Chemical Property of Cefzil

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 220oC
• Refractive Index: 1.718
• Boiling Point: 803.1 °C at 760 mmHg
• Flash Point: 439.5 °C
• PSA: 167.49000
• Density: 1.534g/cm3
• LogP: 1.67150
• Storage Temp.: Store at 0-5°C
• Solubility.: Slightly soluble in water and in methanol, practically insoluble in acetone.
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 407.11510657
• Heavy Atom Count: 28
• Complexity: 699

Purity/Quality:

99% ^*data from raw suppliers

CefprozilMonohydrate(E/ZMixture) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-42/43
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC=CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O.O
• Isomeric SMILES: C/C=C/C1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)SC1)C(=O)O.O
• Recent ClinicalTrials: To Demonstrate the Relative Bioavailability of Cefzil 500 mg Cefprozil Tablets Under Fasting Conditions
• Uses: antidiabetic Semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture. Antibacterial.

Technology Process of Cefzil

There total 3 articles about Cefzil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate (886219-90-5) → cefprozil (114876-72-1,121123-17-9) + (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid monohydrate (111900-24-4,114876-72-1,121123-17-9)

Guidance literature:

In water; for 1h;

Reference yield:

(6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate (886219-90-5) → cefprozil (114876-72-1,121123-17-9) + (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid monohydrate (111900-24-4,114876-72-1,121123-17-9)

Guidance literature:

In water; for 1h;

Reference yield:

7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid DMF solvate → 7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid monohydrate (114876-72-1,121123-17-9)

Guidance literature:

With water; In ethyl acetate; for 1h; Product distribution / selectivity;

upstream raw materials:

(6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate

Refernces

• 1、 -. "Process for preparation of 7-[alpha-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid". Page/Page column 9. . Retrieved 2010/02/11.