886219-90-5

Basic information

• Product Name: (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate
• Synonyms: (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate
• CAS NO: 886219-90-5
• Molecular Weight: 462.527
• Mol File: 886219-90-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate(886219-90-5)
• EPA Substance Registry System: (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate(886219-90-5)

Safety Data

• Hazardous Substances Data: 886219-90-5(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 114876-72-1 cefprozil 
• 111900-24-4 (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid monohydrate 

Relevant articles and documents

A NOVEL PROCESS FOR PREPARATION OF CEFPROZIL INTERMEDIATE

The present invention relates to a process for preparing a key intermediate of cefprozil and use of this intermediate in the preparation of cefprozil thereby avoiding impurity-causing self-acylation. [R-(Z)]-[4-hydroxy-α-[(3-methoxy-l-methyl-3-oxo-1-propenyl)amino]] benzeneacetic acid, mono potassium salt is reacted with ethyl chloroformate to obtain mixed anhydride which is then silylated with N,O-bis(trimethylsilyl)acetamide. The silylated compound obtained is reacted with [7-trimethylsilylamino-3-(Z/E-propen-1-yl)-3-cephem-4-carboxylic acid]trimethylsilyl ester and deprotected with aqueous hydrochloric acid to give cefprozil.