2-Pyridinesulfonamide, N-[6-[(4-hydroxy-2-butynyl)oxy]-5-(2-methoxyphenoxy)-2-(4-morpholinyl)- 4-pyrimidinyl]-5-(1-methylethyl)-

Base Information

Chemical Name:2-Pyridinesulfonamide, N-[6-[(4-hydroxy-2-butynyl)oxy]-5-(2-methoxyphenoxy)-2-(4-morpholinyl)- 4-pyrimidinyl]-5-(1-methylethyl)-
CAS No.:346671-51-0
Molecular Formula:C27H31N5O7S
Molecular Weight:569.638
Hs Code.:
Mol file:346671-51-0.mol

Synonyms:

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Chemical Property of 2-Pyridinesulfonamide, N-[6-[(4-hydroxy-2-butynyl)oxy]-5-(2-methoxyphenoxy)-2-(4-morpholinyl)- 4-pyrimidinyl]-5-(1-methylethyl)-

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Technology Process of 2-Pyridinesulfonamide, N-[6-[(4-hydroxy-2-butynyl)oxy]-5-(2-methoxyphenoxy)-2-(4-morpholinyl)- 4-pyrimidinyl]-5-(1-methylethyl)-

There total 2 articles about 2-Pyridinesulfonamide, N-[6-[(4-hydroxy-2-butynyl)oxy]-5-(2-methoxyphenoxy)-2-(4-morpholinyl)- 4-pyrimidinyl]-5-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-65-6
1,4-dihydroxybut-2-yne

: 179400-99-8
5-isopropyl-pyridine-2-sulfonic acid 6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl-amide

: 346671-51-0
5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-2-(N-morpholino)-4-pyrimidinyl]-2-pyridine sulfonamide

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; citric acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

: Sodium; 4-hydroxy-but-2-yn-1-olate

: 179400-99-8
5-isopropyl-pyridine-2-sulfonic acid 6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl-amide

: 346671-51-0
5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-2-(N-morpholino)-4-pyrimidinyl]-2-pyridine sulfonamide

Guidance literature:: for 32h;
DOI:10.1016/S0960-894X(02)01084-3

Reference yield:

: 15159-40-7
4-morpholinocarbonyl chloride

: 77-92-9,906507-37-7
citric acid

: 346671-51-0
5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-2-(N-morpholino)-4-pyrimidinyl]-2-pyridine sulfonamide

: morpholine-4-carbamic acid 4-[6-(5-isopropyl-pyridine-2-sulfonylamino)-5-(2-methoxy-phenoxy)-2-(N-morpholino)-pyrimidin-4-yloxy]-but-2-ynyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate;