4-Morpholinecarbonyl chloride

Base Information

• Chemical Name: 4-Morpholinecarbonyl chloride
• CAS No.: 15159-40-7
• Molecular Formula: C5H8ClNO2
• Molecular Weight: 149.577
• Hs Code.: 29349990
• European Community (EC) Number: 239-213-0
• NSC Number: 50226
• UNII: Q4BT2G3XS8
• DSSTox Substance ID: DTXSID9065863
• Nikkaji Number: J52.351H
• Wikidata: Q72492826
• Mol file: 15159-40-7.mol

Synonyms:4-Morpholinecarbonyl chloride;15159-40-7;morpholine-4-carbonyl chloride;N-Chlorocarbonylmorpholine;Morpholinocarbonyl chloride;4-Morpholinylcarbonyl Chloride;4-(Chloroformyl)morpholine;Morpholine, 4-(chlorocarbonyl)-;N-Morpholinocarbonyl chloride;Q4BT2G3XS8;morpholine-4-carbonylchloride;4-morpholine-d8-carbonyl chloride;EINECS 239-213-0;NSC 50226;NSC-50226;1219804-24-6;4-Chlorocarbonylmorpholine;4-Morpholinecarbonylchloride;N-Chlorformyl-morpholin;N-chloroformyl-morpholine;morpholine carbonylchloride;morpholinecarbonyl chloride;morpholinecarbonyl-chloride;UNII-Q4BT2G3XS8;(morpholinocarbonyl)chloride;Morpholine carbonyl chloride;morpholine-carbonyl chloride;4-morphlinecarbonyl chloride;SCHEMBL8702;n-morpholinecarbonyl chloride;4-morpholine carbonylchloride;4-morpholine-carbonylchloride;morpholin-4-carbonyl chloride;morpholine N-carbonyl chloride;morpholine-N-carbonyl chloride;N-morpholine carbonyl chloride;4-morpholine carbonyl chloride;4-morpholine-carbonyl chloride;morpholine 4-carbonyl chloride;DTXSID9065863;AMY9689;(morpholin-4-yl)-carbonyl chloride;NSC50226;4-Morpholinecarbonyl chloride, 98%;BBL027926;MFCD00037053;STL373465;Morpholine-4-carboxylic acid chloride;AKOS000120186;FD10526;AS-19544;FT-0658972;M0935;EN300-21372;A809192;W-110406;4-Morpholinecarbonyl chloride, purum, >=98.0% (T);F0001-0542

Chemical Property of 4-Morpholinecarbonyl chloride

Chemical Property:

• Vapor Pressure: 0.0418mmHg at 25°C
• Refractive Index: n20/D 1.498(lit.)
• Boiling Point: 238.7 °C at 760 mmHg
• PKA: -2.16±0.20(Predicted)
• Flash Point: 113.9 °C
• PSA: 29.54000
• Density: 1.304 g/cm³
• LogP: 0.61530
• Storage Temp.: Store below +30°C.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 149.0243562
• Heavy Atom Count: 9
• Complexity: 112

Purity/Quality:

97% ^*data from raw suppliers

4-Morpholinecarbonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 14-36/38-40
• Safety Statements: 26-30-36-38

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCCN1C(=O)Cl
• Uses: Photographic intermediate 4-Morpholinecarbonyl chloride may be used in the preparation of a versatile fluorogenic label for biomolecular imaging. It may be used in the synthesis of:morpholine-4-carboxylic acid [4-(2,4-dimethylphenyl)thiazol-2-yl]amidemorpholine-4-carboxylic acid [4-(2,4,6-trimethylphenyl)thiazol-2-yl]amide2-isopropyl-6-methylpyrimidin-4-yl morpholine-4-carboxylate

Technology Process of 4-Morpholinecarbonyl chloride

There total 20 articles about 4-Morpholinecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

morpholine (110-91-8,99108-56-2) + chloro(chlorosulfanyl)methanone (2757-23-5) → 4-morpholinocarbonyl chloride (15159-40-7)

Guidance literature:

morpholine; chloro(chlorosulfanyl)methanone; In dichloromethane; at 40 ℃; Inert atmosphere;

With chlorine; In dichloromethane; at 20 ℃;

DOI:10.1139/V10-138

Reference yield: 75.3%

morpholine (110-91-8,99108-56-2) + bis(trichloromethyl) carbonate (32315-10-9) → 4-morpholinocarbonyl chloride (15159-40-7)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at -10 ℃;

DOI:10.1007/s11164-012-1003-1

Reference yield: 69.0%

morpholine-4-carboxylic acid ethyl ester (6976-49-4) → 4-morpholinocarbonyl chloride (15159-40-7)

Guidance literature:

With trichlorophosphate; In acetonitrile; for 18h; Heating / reflux;

upstream raw materials:

morpholine

phosgene

morpholine-4-carboxylic acid ethyl ester

4-benzyl-morpholine

Downstream raw materials:

Morpholine-4-carboxylic acid N'-(3,5-bis-trifluoromethyl-phenyl)-hydrazide

(4-morpholinylcarbonyl)-β-phenylserine methyl ester

(Morpholinocarbonyl)phenyl-thiocarbamidsaeure-O-methylester

(morpholin-4-ylcarbonyl)-Thr-D-Trp(CHO)-Phe-NMeBzl