4-Hexynoic acid, 2-amino-, (2R)-

Base Information

• Chemical Name: 4-Hexynoic acid, 2-amino-, (2R)-
• CAS No.: 346707-82-2
• Molecular Formula: C6H9NO2
• Molecular Weight: 127.14100
• Mol file: 346707-82-2.mol

Synonyms:(R)-2-Amino-hex-4-ynoic acid;

Chemical Property of 4-Hexynoic acid, 2-amino-, (2R)-

Chemical Property:

• Boiling Point: 264.4±35.0 °C(Predicted)
• PSA: 63.32000
• Density: 1.160±0.06 g/cm3(Predicted)
• LogP: 0.51200

Purity/Quality:

98% Min ^*data from raw suppliers

(2R)-2-Amino-4-hexynoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hexynoic acid, 2-amino-, (2R)-

There total 6 articles about 4-Hexynoic acid, 2-amino-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(R)-2-amino-4-hexynoic acid amide (771466-51-4) → (R)-2-amino-4-hexynoic acid (346707-82-2)

Guidance literature:

With Rhodococcus erythropolis NCIMB 11540 (whole cells, amidase); In phosphate buffer; at 37 ℃; for 3h; pH=8; Enzymatic reaction;

DOI:10.1002/1615-4169(200108)343:6/7<662::aid-adsc662>3.3.co;2-9

Reference yield:

rac-2-amino-4-hexynoic acid amide (346707-79-7) → (R)-2-amino-4-hexynoic acid (346707-82-2)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / pH 10

2: conc. HCl / acetone

3: KOH; MnSO4; E. coli DH5α/pTrpLAP GMO whole cells (S-aminopeptidase) / H2O; various solvent(s) / 19 h / 40 °C / pH 9.2 / Enzymatic reaction

4: 92 percent / Rhodococcus erythropolis NCIMB 11540 (whole cells, amidase) / aq. phosphate buffer / 3 h / 37 °C / pH 8 / Enzymatic reaction

With hydrogenchloride; potassium hydroxide; sodium hydroxide; manganese(II) sulfate; E. coli DH5α; pTrpLAP GMO whole cells (S-aminopeptidase); Rhodococcus erythropolis NCIMB 11540 (whole cells, amidase); In phosphate buffer; water; acetone;

DOI:10.1002/1615-4169(200108)343:6/7<662::aid-adsc662>3.3.co;2-9

Reference yield:

2-{[1-Phenyl-meth-(E)-ylidene]-amino}-hex-4-ynoic acid amide → (R)-2-amino-4-hexynoic acid (346707-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / acetone

2: KOH; MnSO4; E. coli DH5α/pTrpLAP GMO whole cells (S-aminopeptidase) / H2O; various solvent(s) / 19 h / 40 °C / pH 9.2 / Enzymatic reaction

3: 92 percent / Rhodococcus erythropolis NCIMB 11540 (whole cells, amidase) / aq. phosphate buffer / 3 h / 37 °C / pH 8 / Enzymatic reaction

With hydrogenchloride; potassium hydroxide; manganese(II) sulfate; E. coli DH5α; pTrpLAP GMO whole cells (S-aminopeptidase); Rhodococcus erythropolis NCIMB 11540 (whole cells, amidase); In phosphate buffer; water; acetone;

DOI:10.1002/1615-4169(200108)343:6/7<662::aid-adsc662>3.3.co;2-9

upstream raw materials:

(R)-2-amino-4-hexynoic acid amide

rac-2-amino-4-hexynoic acid amide

2-(benzhydrylidene-amino)-hex-4-ynoic acid methyl ester

Downstream raw materials:

(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 2-((R)-2-tert-butoxycarbonylamino-hex-4-ynoyloxy)benzyl ester

(S)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 2-((S)-2-tert-butoxycarbonylamino-hex-4-ynoyloxy)benzyl ester

(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-((R)-2-tert-butoxycarbonylamino-hex-4-ynoyloxy)benzyl ester

(S)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-((S)-2-tert-butoxycarbonylamino-hex-4-ynoyloxy)benzyl ester