(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester

Base Information

Chemical Name:(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester
CAS No.:346707-74-2
Molecular Formula:C₁₉H₂₅NO₅
Molecular Weight:347.411
Hs Code.:

Synonyms:(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester

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Chemical Property of (R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester

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Technology Process of (R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester

There total 4 articles about (R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 626-18-6
1,3-dimethanol benzene

: 346707-59-3
(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid

: 346707-74-2
(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo001734x

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 346707-74-2
(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / aq. NaOH / dioxane / 3 h / 0 - 20 °C

2: 77 percent / N,N'-dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 0 - 20 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo001734x

Reference yield:

: 346707-82-2
(R)-2-amino-4-hexynoic acid

: 346707-74-2
(R)-2-tert-butoxycarbonylamino-hex-4-ynoic acid 3-hydroxymethylbenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / aq. NaOH / dioxane / 3 h / 0 - 20 °C

2: 77 percent / N,N'-dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 0 - 20 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo001734x