Benzeneacetic acid, 2-acetyl-, ethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 2-acetyl-, ethyl ester
• CAS No.: 3469-05-4
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Hs Code.: 2918300090
• Mol file: 3469-05-4.mol

Synonyms:o-Acetyl-phenylessigsaeure-ethylester;2-Acetyl-phenylessigsaeureaethylester;ethyl (2-acetylphenyl)acetate;

Chemical Property of Benzeneacetic acid, 2-acetyl-, ethyl ester

Chemical Property:

• Boiling Point: 308.4±25.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.083±0.06 g/cm3(Predicted)
• LogP: 1.99480

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, 2-acetyl-, ethyl ester

There total 12 articles about Benzeneacetic acid, 2-acetyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(trimethylsilyl)phenyl sulfofluoridate + ethyl acetoacetate (141-97-9) → ethyl 2-(2-acetylphenyl)acetate (3469-05-4)

Guidance literature:

With 18-crown-6 ether; caesium carbonate; In acetonitrile; at 30 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.joc.5b00923

Reference yield: 61.0%

2-(trimethylsilyl)phenyl imidazol-1-sulfonate (1373397-21-7) + ethyl acetoacetate (141-97-9) → ethyl 2-(2-acetylphenyl)acetate (3469-05-4)

Guidance literature:

With cesium fluoride; In acetonitrile; at 80 ℃; for 1h;

DOI:10.1021/ol300529j

Reference yield: 31.0%

ethyl 3-morpholinobut-2-enoate (36277-32-4,55212-82-3,66003-96-1) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → ethyl 2-(2-acetylphenyl)acetate (3469-05-4)

Guidance literature:

With methanol; cesium fluoride; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1021/ol4018968

upstream raw materials:

Ethyl 2-phenylethanoate

acetyl chloride

ethanol

2-(2-acetylphenyl)acetic acid