1-BROMO-2-ETHYL-4-METHOXY-BENZENE

Base Information

• Chemical Name: 1-BROMO-2-ETHYL-4-METHOXY-BENZENE
• CAS No.: 34881-44-2
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Hs Code.: 2909309090
• Mol file: 34881-44-2.mol

Synonyms:1-Bromo-2-ethyl-4-methoxybenzene;

Chemical Property of 1-BROMO-2-ETHYL-4-METHOXY-BENZENE

Chemical Property:

• PSA: 9.23000
• LogP: 3.02010
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

1-bromo-2-ethyl-4-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-2-ETHYL-4-METHOXY-BENZENE

There total 3 articles about 1-BROMO-2-ETHYL-4-METHOXY-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-bromo-5-dimethoxy-2-vinylbenzene (139469-06-0) → 4-bromo-3-ethyl-1-methoxybezene (34881-44-2)

Guidance literature:

With [2,2]bipyridinyl; palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 0 ℃; for 72h;

DOI:10.1021/jm900752a

Reference yield: 90.0%

3-ethylanisole (10568-38-4) → 4-bromo-3-ethyl-1-methoxybezene (34881-44-2)

Guidance literature:

With N-Bromosuccinimide; silica gel; In tetrachloromethane; at 30 ℃; for 20h;

DOI:10.1246/bcsj.62.591

Reference yield:

→ 4-bromo-3-ethyl-1-methoxybezene (34881-44-2)

Guidance literature:

3-Ethylanisol (2), Br2/Fe-Spaene;

DOI:10.1021/jo00440a028

upstream raw materials:

3-ethylanisole

1-bromo-5-dimethoxy-2-vinylbenzene

Downstream raw materials:

1-butoxy-2-ethyl-4-methoxybenzene

(2-ethyl-4-methoxy)phenylboronic acid

(2-ethyl-4-methoxyphenyl)dimethylsilane

4-(2-Ethyl-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "Process for the preparation of amino acids useful in the preparation of peptide receptor modulators". Page/Page column 1; 3; 5. . Retrieved 2010/02/15.