139469-06-0

Basic information

• Product Name: 1-bromo-4-methoxy-2-vinyl-benzene
• Synonyms: 1-Bromo-4-methoxy-2-vinylbenzene; 4-Bromo-3-vinylphenyl methyl ether; benzene, 1-bromo-2-ethenyl-4-methoxy-
• CAS NO: 139469-06-0
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07
• Mol File: 139469-06-0.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 261.5°C at 760 mmHg
• Flash Point: 113.9°C
• Density: 1.369g/cm³
• Vapor Pressure: 0.0187mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 1-bromo-4-methoxy-2-vinyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-methoxy-2-vinyl-benzene(139469-06-0)
• EPA Substance Registry System: 1-bromo-4-methoxy-2-vinyl-benzene(139469-06-0)

Safety Data

• Hazardous Substances Data: 139469-06-0(Hazardous Substances Data)

Usage

Physical state

Colorless to pale yellow liquid

Odor

Sweet, floral

Usage

Building block in the synthesis of pharmaceuticals and fragrances

Primary application

Chemical intermediate in the production of various compounds (pharmaceuticals, dyes, pesticides)

Additional use

Manufacturing of flavorings and perfumes

Hazardous nature

Potentially hazardous chemical

Safety precautions

Appropriate safety measures should be taken when handling and using it

Upstream product

• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 371114-86-2 4-(2-bromo-5-methoxyphenyl)-2-butanone 
• 50-00-0 formaldehyd 
• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 591-31-1 3-methoxy-benzaldehyde 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 13170-43-9 (trimethylsilyl)methylmagnesium chloride 

Downstream Products

• 75534-35-9 2-(2-bromo-5-methoxyphenyl)ethan-1-ol 
• 90843-19-9 4-methoxy-2-vinylbenzaldehyde 
• 1373919-34-6 4-methoxy-2-vinylbenzonitrile 
• 1400742-98-4 C₁₅H₂₂BBrO₃ 
• 66164-29-2 4-methoxy-1-methyl-2-vinylbenzene 
• 1527523-54-1 (1R,3aS,4R,5S,7aR)-4-(5-methoxy-2-methylphenethyl)-7a-methyl-1-((R)-6-methylheptan-2-yl)-octahydro-1H-inden-5-ol 
• 328570-91-8 (1R,3aS,4S,5R,7aR)-4-(5-methoxy-2-methylphenethyl)-7a-methyl-1-((R)-6-methylheptan-2-yl)-octahydro-1H-inden-5-ol 
• 33348-61-7 2-(5-methoxy-2-methylphenyl)ethanol 
• 89691-66-7 1-(5-methoxy-2-methylphenyl)ethanol 
• 1352331-60-2 2-(2-bromoethyl)-4-methoxy-1-methylbenzene 
• 1246640-85-6 C₆H₃(Sn(C₄H₉)3)(OCH₃)(CHCH₂) 
• 34881-44-2 4-bromo-3-ethyl-1-methoxybezene 

Relevant articles and documents

Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones

The dehydroacylation of ketones to olefins is realized under mild conditions, which exhibits a unique reaction pathway involving aromatization-driven C-C cleavage to remove the acyl moiety, followed by Cu-mediated oxidative elimination to form an alkene between the α and β carbons. The newly adopted N′-methylpicolinohydrazonamide (MPHA) reagent is key to enable efficient cleavage of ketone C-C bonds at room temperature. Diverse alkyl- and aryl-substituted olefins, dienes, and special alkenes are generated with broad functional group tolerance. Strategic applications of this method are also demonstrated.

Sequential Addition of Amines to Nitrile and Carbon-Carbon Multiple Bond: A Route to 7-Amino-5 H-dibenzo[ c,e]azepines

A rare earth metal-catalyzed sequential inter- and intramolecular C-N bond formation of 2-nitrile-2′-alkenyl(alkynyl)biphenyls with amines has been developed, which provides a straightforward and efficient access to a range of new functional dibenzo[c,e]azepines. This represents the first examples of direct construction of seven-membered azaheterocycle from unsaturated nitriles and amines. Such transformations have the advantages of avoiding the use of additives, easily available starting materials, step- and high atom-economy, mild reaction conditions, and high selectivity.

Stereoselective Convergent Synthesis of Tetrahydro-5 H-benzo[c]fluorene via Nine-Membered Ring-Closing Metathesis and Transannular Acid-Mediated Cyclization/Nucleophilic Addition

The diene methyl ethers or acetates, constructed from the Li-Br exchange/addition reactions of 2-vinylbenzaldehydes and 2-(but-3-en-1-yl)bromoarenes followed by etherification or acetylation of the corresponding alcohols, smoothly underwent the ring-closi