2-Propenamide, N,N-dimethyl-3-(4-methylphenyl)-, (2E)-

Base Information

• Chemical Name: 2-Propenamide, N,N-dimethyl-3-(4-methylphenyl)-, (2E)-
• CAS No.: 34909-37-0
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• DSSTox Substance ID: DTXSID60359405
• Mol file: 34909-37-0.mol

Synonyms:2-Propenamide, N,N-dimethyl-3-(4-methylphenyl)-, (2E)-;DTXSID60359405;AKOS017262630

Chemical Property of 2-Propenamide, N,N-dimethyl-3-(4-methylphenyl)-, (2E)-

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 189.115364102
• Heavy Atom Count: 14
• Complexity: 212

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C=CC(=O)N(C)C

Technology Process of 2-Propenamide, N,N-dimethyl-3-(4-methylphenyl)-, (2E)-

There total 18 articles about 2-Propenamide, N,N-dimethyl-3-(4-methylphenyl)-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trans-p-methylcinnamic acid (1866-39-3,940-61-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (E)-N,N-dimethyl-3-(p-tolyl)acrylamide (34909-37-0)

Guidance literature:

With tert.-butylhydroperoxide; copper diacetate; In 1,1,2-trichloroethane; at 90 ℃; for 12h;

DOI:10.1016/j.tetlet.2013.09.016

Reference yield: 85.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 4-Methylbenzyl alcohol (589-18-4) → (E)-N,N-dimethyl-3-(p-tolyl)acrylamide (34909-37-0)

Guidance literature:

With sodium hydride; chlorobenzene; NiCl₂(1,10-phenanthroline); at 20 ℃;

DOI:10.1081/SCC-100104004

Reference yield: 85.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (E)-N,N-dimethyl-3-(p-tolyl)acrylamide (34909-37-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; iron(III) chloride; di-tert-butyl peroxide; In neat (no solvent); at 110 ℃; for 48h; Reagent/catalyst; chemoselective reaction; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4cc05051g

upstream raw materials:

N,N-dimethyl-formamide

4-n-methylphenylacetylene

N,N-Dimethylacrylamide

toluene