(R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 350508-38-2
• Molecular Formula: C10H13N
• Molecular Weight: 147.21700
• Mol file: 350508-38-2.mol

Synonyms:(R)-4-methyl-1,2,3,4-tetrahydroisoquinoline;

Chemical Property of (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

• PSA: 12.03000
• LogP: 2.22210

Purity/Quality:

95+% ^*data from raw suppliers

(4S)-4-Methyl-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline

There total 17 articles about (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1'R,4S)-2-(2'-hydroxy-1'-phenylethyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline (503822-45-5) → (R)-4-methyl-1,2,3,4-tetrahydroisoquinoline (350508-38-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 14h; under 760 Torr;

DOI:10.3987/com-02-s(m)42

Reference yield: 48.6%

(4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline (1492030-94-0) → (R)-4-methyl-1,2,3,4-tetrahydroisoquinoline (350508-38-2)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; at 20 ℃; for 3.16667h; Reflux;

DOI:10.1021/ol4013537

Reference yield:

(R)-4-methyl-3,4-dihydroisoquinolin-1(2H)-one → (R)-4-methyl-1,2,3,4-tetrahydroisoquinoline (350508-38-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.0c06756

upstream raw materials:

(1'R,4S)-2-(2'-hydroxy-1'-phenylethyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline

(3R,6R)-6-methyl-3-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline

(2R,4R)-3-allyl-2-(2-bromophenyl)-4-phenyl-1,3-oxazolidine

ortho-bromobenzaldehyde