(4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1492030-94-0
Molecular Formula:C₁₇H₁₉N
Molecular Weight:237.345
Hs Code.:

Synonyms:(4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about (4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: dibenzyl[(2S)-2-bromopropyl]amine

: (4S)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

: 1492030-94-0
(4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With ferric(III) bromide; In toluene; at 0 ℃; for 14h; Overall yield = 25.3 %; Overall yield = 9.6 mg; enantioselective reaction; Reflux;
DOI:10.1021/ol4013537

Reference yield:

: 60479-64-3
2(R)--1-propanol

: (4S)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

: 1492030-94-0
(4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; triphenylphosphine / chloroform / 0 - 20 °C

2: ferric(III) bromide / toluene / 14 h / 0 °C / Reflux

With N-Bromosuccinimide; ferric(III) bromide; triphenylphosphine; In chloroform; toluene; 2: |Friedel-Crafts Alkylation;
DOI:10.1021/ol4013537

Reference yield:

: 100-39-0
benzyl bromide

: (4S)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

: 1492030-94-0
(4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 0 - 20 °C

2: N-Bromosuccinimide; triphenylphosphine / chloroform / 0 - 20 °C

3: ferric(III) bromide / toluene / 14 h / 0 °C / Reflux

With N-Bromosuccinimide; ferric(III) bromide; potassium carbonate; triphenylphosphine; In chloroform; toluene; acetonitrile; 3: |Friedel-Crafts Alkylation;
DOI:10.1021/ol4013537