4-Morpholinecarboxylic acid, 3-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(phenylmethyl)amino]propyl ]-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-

Base Information

Chemical Name:4-Morpholinecarboxylic acid, 3-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(phenylmethyl)amino]propyl ]-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-
CAS No.:351020-28-5
Molecular Formula:C40H48N2O5Si
Molecular Weight:664.917
Hs Code.:

4-Morpholinecarboxylic acid,
3-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(phenylmethyl)amino]propyl
]-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-

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Chemical Property of 4-Morpholinecarboxylic acid, 3-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(phenylmethyl)amino]propyl ]-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-

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Technology Process of 4-Morpholinecarboxylic acid, 3-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(phenylmethyl)amino]propyl ]-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-

There total 3 articles about 4-Morpholinecarboxylic acid, 3-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(phenylmethyl)amino]propyl ]-2-oxo-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 100516-54-9,335159-14-3
(5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 121904-08-3
3-(tert-butyldimethylsiloxy)-N-benzyl-propanaldimine

: 351020-28-5
(3S,5S,6R)-3-[1-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Guidance literature:: (5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one; With lithium hexamethyldisilazane;

With dimethylaluminum chloride;

3-(tert-butyldimethylsiloxy)-N-benzyl-propanaldimine; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1016/S0040-4039(01)00487-7

Reference yield:

: 89922-82-7
3-(tert-butyldimethylsilanyloxy)propionaldehyde

: 351020-28-5
(3S,5S,6R)-3-[1-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / alumina / CH₂Cl₂ / 0.42 h / 0 °C

2.1: lithium bis(trimethylsilyl)amide

2.2: dimethylaluminum chloride

2.3: 60 percent / tetrahydrofuran / 1 h / -78 °C

With aluminum oxide; lithium hexamethyldisilazane; In dichloromethane; 2.3: Mannich reaction;
DOI:10.1016/S0040-4039(01)00487-7

Reference yield:

: 100-46-9
benzylamine

: 351020-28-5
(3S,5S,6R)-3-[1-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / alumina / CH₂Cl₂ / 0.42 h / 0 °C

2.1: lithium bis(trimethylsilyl)amide

2.2: dimethylaluminum chloride

2.3: 60 percent / tetrahydrofuran / 1 h / -78 °C

With aluminum oxide; lithium hexamethyldisilazane; In dichloromethane; 2.3: Mannich reaction;
DOI:10.1016/S0040-4039(01)00487-7