2,6-Bis(4-chlorophenyl)-1-methyl-4-piperidinone

Base Information

• Chemical Name: 2,6-Bis(4-chlorophenyl)-1-methyl-4-piperidinone
• CAS No.: 3518-84-1
• Molecular Formula: C₁₈H₁₇Cl₂NO
• Molecular Weight: 334.245
• DSSTox Substance ID: DTXSID301242880
• Mol file: 3518-84-1.mol

Synonyms:2,6-Bis(4-chlorophenyl)-1-methyl-4-piperidinone;DTXSID301242880;3518-84-1;2,6-bis(4-chlorophenyl)-1-methylpiperidin-4-one

Chemical Property of 2,6-Bis(4-chlorophenyl)-1-methyl-4-piperidinone

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 333.0687196
• Heavy Atom Count: 22
• Complexity: 353

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C(CC(=O)CC1C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl

Technology Process of 2,6-Bis(4-chlorophenyl)-1-methyl-4-piperidinone

There total 3 articles about 2,6-Bis(4-chlorophenyl)-1-methyl-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 2,6-bis-(4-chloro-phenyl)-1-methyl-piperidin-4-one (3518-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OAc / ethanol / 32 h

2: K₂CO₃

With ammonium acetate; potassium carbonate; In ethanol;

DOI:10.1016/j.ejmech.2005.02.001

Reference yield:

2,6-Bis-(4-chloro-phenyl)-piperidin-4-one (597577-90-7) + methyl iodide (74-88-4) → 2,6-bis-(4-chloro-phenyl)-1-methyl-piperidin-4-one (3518-84-1)

Guidance literature:

With potassium carbonate;

DOI:10.1016/j.ejmech.2005.02.001

Reference yield:

→ 2,6-bis-(4-chloro-phenyl)-1-methyl-piperidin-4-one (3518-84-1)

Guidance literature:

1,3-Bis-<4-chlor-benzyliden>-aceton, Methylamin;

DOI:10.1021/jm00329a015

upstream raw materials:

2,6-Bis-(4-chloro-phenyl)-piperidin-4-one

methyl iodide

4-chlorobenzaldehyde

Downstream raw materials:

2,6-bis(4-chlorophenyl)-1-methylpiperidin-4-thiosemicarbazone

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