N-(3-cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-2-phenylacetamide

Base Information

Chemical Name:N-(3-cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-2-phenylacetamide
CAS No.:353484-29-4
Molecular Formula:C₁₈H₁₈N₂O₂S
Molecular Weight:326.419
Hs Code.:
DSSTox Substance ID:DTXSID901321406
ChEMBL ID:CHEMBL1723525
Mol file:353484-29-4.mol

Synonyms:Oprea1_271753;MLS000779669;CHEMBL1723525;DTXSID901321406;HMS2808P07;STL323608;AKOS022102595;N-(3-cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-2-phenylacetamide;353484-29-4;SMR000419852;N-(3-Cyano-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-2-phenyl-acetamide;N-(3-cyano-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-2-phenylacetamide

Suppliers and Price of N-(3-cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-2-phenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-2-phenylacetamide

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:326.10889899
Heavy Atom Count:23
Complexity:493

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CC2=C(CO1)SC(=C2C#N)NC(=O)CC3=CC=CC=C3)C

Technology Process of N-(3-cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-2-phenylacetamide

There total 1 articles about N-(3-cyano-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-2-yl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

: 65413-45-8
2-amino-5,5-dimethyl-3-cyano-4,5-dihydro-7H-thieno<2,3-c>pyran

: 103-80-0
phenylacetyl chloride

: 353484-29-4
N-(3-cyano-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-2-phenyl-acetamide

Guidance literature:: In benzene; for 4h; Heating;
DOI:10.1007/s10593-005-0133-4

Reference yield:

: 353484-29-4
N-(3-cyano-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-2-phenyl-acetamide

: 2-(2-benzyl-6,6-dimethyl-5,8-dihydro-6H-7-oxa-9-thia-1,3-diaza-fluoren-4-ylsulfanyl)-N-(4-bromo-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83.1 percent / H₂S; Et₃N; pyridine / 8 h / 80 °C

2: 84.5 percent / KOH / aq. ethanol

With pyridine; potassium hydroxide; hydrogen sulfide; triethylamine; In ethanol;
DOI:10.1007/s10593-005-0133-4

Reference yield:

: 353484-29-4
N-(3-cyano-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-2-phenyl-acetamide

: N-benzhydryl-2-(2-benzyl-6,6-dimethyl-5,8-dihydro-6H-7-oxa-9-thia-1,3-diaza-fluoren-4-ylsulfanyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83.1 percent / H₂S; Et₃N; pyridine / 8 h / 80 °C

2: 72.2 percent / KOH / aq. ethanol

With pyridine; potassium hydroxide; hydrogen sulfide; triethylamine; In ethanol;
DOI:10.1007/s10593-005-0133-4