2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-, dimethyl ester, (2S,4S,5R)-

Base Information

Chemical Name:2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-, dimethyl ester, (2S,4S,5R)-
CAS No.:353494-43-6
Molecular Formula:C₂₂H₂₈N₂O₇
Molecular Weight:432.474
Hs Code.:

2,4-Pyrrolidinedicarboxylic acid,
5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2
-methyl-, dimethyl ester, (2S,4S,5R)-

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Chemical Property of 2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-, dimethyl ester, (2S,4S,5R)-

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Technology Process of 2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-, dimethyl ester, (2S,4S,5R)-

There total 3 articles about 2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-, dimethyl ester, (2S,4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: (S)-2-{[1-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-meth-(E)-ylidene]-amino}-propionic acid methyl ester

: 353494-43-6
(2S,4S,5R)-5-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2-methyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

: (2R,4R,5S)-5-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2-methyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: With silver(I) acetate; triethylamine;
DOI:10.1055/s-2001-14611

Reference yield:

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: (S)-2-{[1-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-meth-(E)-ylidene]-amino}-propionic acid methyl ester

: 353494-43-6
(2S,4S,5R)-5-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2-methyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: With silver(I) acetate; triethylamine; In toluene; at 20 ℃; for 40h;
DOI:10.1021/jo026112l

Reference yield:

: 221909-59-7
(+)-(3R,4R)-4-formyl-3-allyloxy-1-(p-methoxyphenyl)-2-azetidinone

: 353494-43-6
(2S,4S,5R)-5-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2-methyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / 20 °C

2: 200 mg / silver acetate; triethylamine / toluene / 40 h / 20 °C

With 4 A molecular sieve; silver(I) acetate; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jo026112l