2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-1-(1-oxo-2-propenyl)-, dimethyl ester, (2S,4S,5R)-

Base Information

Chemical Name:2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-1-(1-oxo-2-propenyl)-, dimethyl ester, (2S,4S,5R)-
CAS No.:353494-53-8
Molecular Formula:C25H30N2O8
Molecular Weight:486.522
Hs Code.:

2,4-Pyrrolidinedicarboxylic acid,
5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2
-methyl-1-(1-oxo-2-propenyl)-, dimethyl ester, (2S,4S,5R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-1-(1-oxo-2-propenyl)-, dimethyl ester, (2S,4S,5R)-

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Technology Process of 2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-1-(1-oxo-2-propenyl)-, dimethyl ester, (2S,4S,5R)-

There total 4 articles about 2,4-Pyrrolidinedicarboxylic acid, 5-[(2S,3R)-1-(4-methoxyphenyl)-4-oxo-3-(2-propenyloxy)-2-azetidinyl]-2 -methyl-1-(1-oxo-2-propenyl)-, dimethyl ester, (2S,4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 814-68-6,25189-84-8
acryloyl chloride

: (S)-2-{[1-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-meth-(E)-ylidene]-amino}-propionic acid methyl ester

: 353494-53-8
(2S,4S,5R)-1-Acryloyl-5-[(2S,3R)-3-allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2-methyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: acrylic acid methyl ester; (S)-2-{[1-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-meth-(E)-ylidene]-amino}-propionic acid methyl ester; With silver(I) acetate; triethylamine; In toluene; at 20 ℃; for 40h;

acryloyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 3h; Further stages.;
DOI:10.1021/jo026112l

Reference yield: 88.0%

: 814-68-6,25189-84-8
acryloyl chloride

: 353494-43-6
(2S,4S,5R)-5-[(2S,3R)-3-Allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2-methyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

: 353494-53-8
(2S,4S,5R)-1-Acryloyl-5-[(2S,3R)-3-allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2-methyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: With triethylamine;
DOI:10.1055/s-2001-14611

Reference yield:

: 221909-59-7
(+)-(3R,4R)-4-formyl-3-allyloxy-1-(p-methoxyphenyl)-2-azetidinone

: 353494-53-8
(2S,4S,5R)-1-Acryloyl-5-[(2S,3R)-3-allyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-2-methyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / 20 °C

2.1: silver acetate; triethylamine / toluene / 40 h / 20 °C

2.2: 88 percent / triethylamine / CH₂Cl₂ / 3 h / 0 °C

With 4 A molecular sieve; silver(I) acetate; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jo026112l