ethyl 3-broMo-5-fluorobenzoate

Base Information

• Chemical Name: ethyl 3-broMo-5-fluorobenzoate
• CAS No.: 353743-43-8
• Molecular Formula: C9H8BrFO2
• Molecular Weight: 247.064
• Hs Code.: 2916399090
• Mol file: 353743-43-8.mol

Synonyms:3-Bromo-1,2-diamino-5-fluorobenzene;3-bromo-5-fluoro-benzene-1,2-diamine;1,2-diamino-3-bromo-5-fluorobenzene;3-bromo-5-fluoro-1,2-diaminobenzene;ethyl 3-bromo-5-fluoro-benzoate;3-bromo-5-fluorobenzoic acid ethyl ester;3-bromo-5-fluoro-1,2-phenylenediamine;

Chemical Property of ethyl 3-broMo-5-fluorobenzoate

Chemical Property:

• Boiling Point: 268.4±25.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.504±0.06 g/cm3(Predicted)
• LogP: 2.76490

Purity/Quality:

99.90% ^*data from raw suppliers

Ethyl3-Bromo-5-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-broMo-5-fluorobenzoate

There total 4 articles about ethyl 3-broMo-5-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-bromo-5-fluorobenzoic acid (176548-70-2) + ethanol (64-17-5) → ethyl 3-bromo-5-fluorobenzoate (353743-43-8)

Guidance literature:

With sulfuric acid; at 20 ℃; for 16h; Reflux;

Reference yield: 39.0%

→ ethyl 3-bromo-5-fluorobenzoate (353743-43-8)

Guidance literature:

With 1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate; [Cu(^tBuCN)₂OTf]; silver fluoride; In tetrahydrofuran; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

C15H20BBrO4 → ethyl 3-bromo-5-fluorobenzoate (353743-43-8)

Guidance literature:

With 1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate; (tBuCN)2Cu*OTf; silver fluoride; In tetrahydrofuran; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ja310909q

upstream raw materials:

3-bromo-5-fluorobenzoic acid

ethanol

ethyl 3-bromobenzoate

Downstream raw materials:

3-bromo-5-morpholin-4-yl-benzoic acid ethyl ester

ethyl 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate