4-HYDROXY-6-METHYL-3-NITRO-2-PYRIDONE

Base Information

• Chemical Name: 4-HYDROXY-6-METHYL-3-NITRO-2-PYRIDONE
• CAS No.: 4966-90-9
• Molecular Formula: C6H6N2O4
• Molecular Weight: 170.125
• Hs Code.: 29333999
• Mol file: 4966-90-9.mol

Synonyms:2,4-Pyridinediol,6-methyl-3-nitro- (7CI,8CI);3-Nitro-6-methylpyridine-2,4-diol;4-Hydroxy-6-methyl-3-nitro-2(1H)-pyridinone;4-Hydroxy-6-methyl-3-nitro-2-pyridone;6-Methyl-3-nitropyridine-2,4-diol;

Chemical Property of 4-HYDROXY-6-METHYL-3-NITRO-2-PYRIDONE

Chemical Property:

• Appearance/Colour: Yellow powder
• Vapor Pressure: 0.00125mmHg at 25°C
• Melting Point: 293-296 °C(lit.)
• Refractive Index: 1.608
• Boiling Point: 265.6 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 114.4 °C
• PSA: 98.91000
• Density: 1.53 g/cm³
• LogP: 0.82030
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Solubility in N,N-DMF gives very faint turbidity.

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-6-methyl-3-nitro-2-pyridone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Hydroxy-6-methyl-3-nitro-2-pyridone may be used as a reactant in the synthesis of pyridylthiazole derivative and 4-chloro-6-methyl-3-nitro-2-pyridone.

Technology Process of 4-HYDROXY-6-METHYL-3-NITRO-2-PYRIDONE

There total 6 articles about 4-HYDROXY-6-METHYL-3-NITRO-2-PYRIDONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7) → 4-hydroxy-6-methyl-3-nitro-2(1H)-pyridinone (4966-90-9)

Guidance literature:

With nitric acid; sodium nitrite; In acetic acid; at 20 ℃; for 0.5h;

DOI:10.1002/jhet.5570370537

Reference yield:

4-hydroxy-6-methyl-2-pyron (675-10-5) → 4-hydroxy-6-methyl-3-nitro-2(1H)-pyridinone (4966-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 25 percent aq. ammonium hydroxide / 6 h / 100 °C

2: 72 percent / conc. HNO₃; NaNO₂ / acetic acid / 0.5 h / 20 °C

With ammonium hydroxide; nitric acid; sodium nitrite; In acetic acid;

DOI:10.1002/jhet.5570370537

Reference yield:

4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7) → 2,4-Dihydroxy-6-methyl-3-nitropyridine (4966-90-9)

Guidance literature:

With nitric acid;

upstream raw materials:

4-hydroxy-6-methyl-2-pyridone

2,4-dihydroxy-6-methylpyridine

4-hydroxy-6-methyl-2-pyron

Downstream raw materials:

4-chloro-2-hydroxy-6-methyl-3-nitropyridine

2,4-dichloro-6-methyl-3-nitropyridine

benzenesulfonic acid 2-hydroxy-6-methyl-3-nitro-pyridin-4-yl ester

2,4-dibromo-6-methyl-3-nitropyridine