4(3H)-Quinazolinone, 3-(3-methylphenyl)-2-(methylthio)-

Base Information

• Chemical Name: 4(3H)-Quinazolinone, 3-(3-methylphenyl)-2-(methylthio)-
• CAS No.: 361179-11-5
• Molecular Formula: C16H14N2OS
• Molecular Weight: 282.36000
• Mol file: 361179-11-5.mol

Synonyms:2-methylsulfanyl-3-m-tolyl-3H-quinazolin-4-one;2-methylthio-3-(3-methylphenyl)quinazolin-4(3H)-one;

Chemical Property of 4(3H)-Quinazolinone, 3-(3-methylphenyl)-2-(methylthio)-

Chemical Property:

• PSA: 60.19000
• LogP: 3.41600

Purity/Quality:

3-(3-METHYLPHENYL)-2-METHYLSULFANYLQUINAZOLIN-4-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(3H)-Quinazolinone, 3-(3-methylphenyl)-2-(methylthio)-

There total 1 articles about 4(3H)-Quinazolinone, 3-(3-methylphenyl)-2-(methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

dimethyl sulfate (77-78-1) + 2-thioxo-3-(3-methylphenyl)quinazolin-4(3H)-one (37641-49-9) → 2-methylthio-3-(3-methylphenyl)quinazolin-4(3H)-one (361179-11-5)

Guidance literature:

In sodium hydroxide; ethanol; for 1h;

DOI:10.1248/bpb.28.1531

Reference yield: 76.0%

2-methylthio-3-(3-methylphenyl)quinazolin-4(3H)-one (361179-11-5) → 2-hydrazino-3-(3-methylphenyl)quinazolin-4(3H)-one (67443-13-4)

Guidance literature:

With potassium carbonate; hydrazine hydrate; In ethanol; for 30h; Heating;

DOI:10.1248/bpb.28.1531

Reference yield:

2-methylthio-3-(3-methylphenyl)quinazolin-4(3H)-one (361179-11-5) → 1-ethyl-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / hydrazine hydrate; K₂CO₃ / ethanol / 30 h / Heating

2: 77.4 percent / 34 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol;

DOI:10.1248/bpb.28.1531

upstream raw materials:

dimethyl sulfate

2-thioxo-3-(3-methylphenyl)quinazolin-4(3H)-one

Downstream raw materials:

2-hydrazino-3-(3-methylphenyl)quinazolin-4(3H)-one

1-methyl-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-one

4-(m-tolyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one