67443-13-4

Basic information

• Product Name: 2,4(1H,3H)-Quinazolinedione, 3-(3-methylphenyl)-, 2-hydrazone
• CAS NO: 67443-13-4
• Molecular Formula: C15H14N4O
• Molecular Weight: 266.302
• Mol File: 67443-13-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Quinazolinedione, 3-(3-methylphenyl)-, 2-hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Quinazolinedione, 3-(3-methylphenyl)-, 2-hydrazone(67443-13-4)
• EPA Substance Registry System: 2,4(1H,3H)-Quinazolinedione, 3-(3-methylphenyl)-, 2-hydrazone(67443-13-4)

Safety Data

• Hazardous Substances Data: 67443-13-4(Hazardous Substances Data)

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 20976-00-5 N-(3-methylphenyl)methyldithiocarbamic acid 
• 37641-49-9 2-thioxo-3-(3-methylphenyl)quinazolin-4(3H)-one 
• 361179-11-5 2-methylthio-3-(3-methylphenyl)quinazolin-4(3H)-one 
• 37641-49-9 2-sulfhydryl-3-(3-methylphenyl)-quinazolin-4(3H)-one 

Downstream Products

• 1262235-80-2 C₁₆H₁₃N₅O 
• 85772-17-4 4-(m-tolyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one 
• 85772-18-5 (5-Oxo-4-m-tolyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)-acetic acid ethyl ester 
• 68357-49-3 1-methyl-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-one 
• 67442-91-5 1-mercapto-4-(m-tolyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one 
• 77066-32-1 1-Hydroxy-4-m-tolyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one 

Relevant articles and documents

Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives

A series of 4-(substituted-phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones (6a-x) with triazole and other heterocyclic substituents (7-14) were synthesized and the compounds were evaluated for their anticonvulsant activity and neurotoxicity by maximal electroshock (MES) and rotarod neurotoxicity tests. Among the compounds studied, 6o and 6q showed wide margins of safety with protective indices (PIs) that were much higher than those of currently used drugs (PI6o > 25.5, PI6q > 26.0). Compounds 6o and 6q showed significant oral activity against MES-induced seizures in mice, with ED50 values of 88.02 and 94.6 mg/kg, respectively. The two compounds were also found to have potent activity against seizures that were induced by pentylenetetrazole and bicuculline. A series of 4-(substituted-phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones with triazole and other heterocyclic substituents were synthesized and the compounds were evaluated for their anticonvulsant activity and neurotoxicity using maximal electroshock and rotarod neurotoxicity tests.

Synthesis and H1-antihistaminic activity of some novel 1-substituted-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones

A series of novel 1-substituted-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a] quinazolin-5(4H)-ones were synthesized by the cyclization of 2-hydrazino-3-(3-methylphenyl) quinazolin-4(3H)-one with various one carbon donors. The starting material 2-hydrazino-3-(