1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE

Base Information

Chemical Name:1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE
CAS No.:365242-43-9
Molecular Formula:C₁₂H₇F₃O₂S
Molecular Weight:272.248
Hs Code.:
Mol file:365242-43-9.mol

Synonyms:2-Trifluoromethyl-1,2-dihydro-thieno[2,3-c]chromen-4-one;

Suppliers and Price of 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE

Chemical Property:

Melting Point:146 - 147 °C (ethanol)
PSA：55.51000
LogP:3.37210

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE

There total 2 articles about 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 623-51-8
ethyl 2-sulfanylacetate

: 151668-40-5
2-trifluoromethyl-4-chromone

: 365242-43-9
2-(trifluoromethyl)-1,2-dihydro-4H-thieno[2,3-c]chromen-4-one

Guidance literature:: With triethylamine; at 80 ℃; for 30h;
DOI:10.1016/S0040-4039(01)00946-7

Reference yield: 85.0%

: 623-51-8
ethyl 2-sulfanylacetate

: 151668-40-5
2-trifluoromethyl-4-chromone

: 1665-65-2
diethyl 2,2'-disulfanediyldiacetate

: 365242-43-9
2-(trifluoromethyl)-1,2-dihydro-4H-thieno[2,3-c]chromen-4-one

Guidance literature:: With triethylamine; at 80 ℃; for 12h;
DOI:10.1016/S0040-4020(03)00329-6

Reference yield:

: 365242-43-9
2-(trifluoromethyl)-1,2-dihydro-4H-thieno[2,3-c]chromen-4-one

: 2-(6-hydrazinopyridazin-3-yl)-4-nitrophenol

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / 33percent H₂O₂; glacial acetic acid / 2 h / 100 °C

2: 94 percent / HNO₃; H₂SO₄ / 0.17 h / 20 °C

3: 73 percent / hydrazine hydrate / ethanol / 0.25 h / Heating

With sulfuric acid; nitric acid; hydrazine hydrate; acetic acid; In ethanol;
DOI:10.1021/jo0258406