2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

Base Information

Chemical Name:2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide
CAS No.:36811-56-0
Molecular Formula:C13H11ClN2O2S
Molecular Weight:294.75700
Hs Code.:
European Community (EC) Number:609-295-6
DSSTox Substance ID:DTXSID00464163
Nikkaji Number:J2.894.110B
Mol file:36811-56-0.mol

Synonyms:36811-56-0;2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide;2-Amino-N-(3-(2-chlorobenzoyl)thiophen-2-yl)acetamide;2-aminoacetylamino-3-(o-chlorobenzoyl)-thiophene;SCHEMBL5443960;DTXSID00464163;RUWGIIBJPFGBPL-UHFFFAOYSA-N;AKOS016023798

Suppliers and Price of 2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-N-(3-(2-chlorobenzoyl)thiophen-2-yl)acetamide
10mg
$ 195.00

TRC
2-Amino-N-(3-(2-chlorobenzoyl)thiophen-2-yl)acetamide
100mg
$ 1540.00

Medical Isotopes, Inc.
2-Amino-N-(3-(2-chlorobenzoyl)thiophen-2-yl)acetamide
10 mg
$ 675.00

Total 3 raw suppliers

Chemical Property of 2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

Chemical Property:

Vapor Pressure:2.02E-12mmHg at 25°C
Boiling Point:556.5oC at 760 mmHg
Flash Point:290.3oC
PSA：103.92000
Density:1.432g/cm3
LogP:3.87950
Solubility.:DMSO, Ethyl Acetate, Methanol
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:294.0229765
Heavy Atom Count:19
Complexity:354

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-N-(3-(2-chlorobenzoyl)thiophen-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)C2=C(SC=C2)NC(=O)CN)Cl
Uses 2-Amino-N-(3-(2-chlorobenzoyl)thiophen-2-yl)acetamide is an intermediate in the synthesis of Brotizolam (B689280), a hypnotic and sedative used in veterinary medicine as an appetite stimulant.

Technology Process of 2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

There total 4 articles about 2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 53265-13-7
3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene

: 36811-56-0
2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

Guidance literature:: With hydrazine hydrate; In methanol; chloroform; water; 1) 45 deg C, 10 min, 2) 60 deg C, 1,5 h, 3) standing overnight;
DOI:10.1135/cccc19840621

Reference yield:

: 40017-59-2
[2-(2-chloro-acetylamino)-thiophen-3-yl]-(2-chloro-phenyl)-methanone

: 36811-56-0
2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

Guidance literature:: With sodium iodide; In dichloromethane; ammonia; acetone;

Reference yield:

: 40017-58-1
2-Amino-3-(o-chlorobenzoyl)-thiophene

: 36811-56-0
2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / CHCl₃ / 1) after mixing slowly heated and refluxed 2 h, 2) standing overnight

2: 58 percent / hydrazine hydrate / methanol; CHCl₃; H₂O / 1) 45 deg C, 10 min, 2) 60 deg C, 1,5 h, 3) standing overnight

With hydrazine hydrate; In methanol; chloroform; water;
DOI:10.1135/cccc19840621