2-Amino-3-(2-chlorobenzoyl)thiophene

Base Information

Chemical Name:2-Amino-3-(2-chlorobenzoyl)thiophene
CAS No.:40017-58-1
Molecular Formula:C11H8ClNOS
Molecular Weight:237.70
Hs Code.:2934999090
European Community (EC) Number:609-770-8
DSSTox Substance ID:DTXSID20356612
Nikkaji Number:J2.866.835J
Wikidata:Q72434355
Mol file:40017-58-1.mol

Synonyms:40017-58-1;2-AMINO-3-(2-CHLOROBENZOYL)THIOPHENE;(2-aminothiophen-3-yl)-(2-chlorophenyl)methanone;(2-aminothiophen-3-yl)(2-chlorophenyl)methanone;(2-Amino-3-thienyl)-(2-chlorophenyl)methanone;Oprea1_731459;SCHEMBL5434275;DTXSID20356612;MFCD00837315;2-amino-3-(o-chlorobenzoyl)thiophene;AKOS000281965;3-(2-CHLOROBENZOYL)THIOPHEN-2-AMINE;CS-0357132;FT-0661673;(2-Aminothiophene-3-yl)(2-chlorophenyl)methanone

Suppliers and Price of 2-Amino-3-(2-chlorobenzoyl)thiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-3-(2-chlorobenzoyl)thiophene
100 mg
$ 125.00

TRC
2-Amino-3-(2-chlorobenzoyl)thiophene
250 mg
$ 300.00

Medical Isotopes, Inc.
2-Amino-3-(2-chlorobenzoyl)thiophene
100 mg
$ 870.00

Crysdot
2-Amino-3-(2-chlorobenzoyl)thiophene 95+%
1g
$ 791.00

Chemenu
2-Amino-3-(2-chlorobenzoyl)thiophene 95%
1g
$ 747.00

Biosynth Carbosynth
2-Amino-3-(2-chlorobenzoyl)thiophene
1 g
$ 1310.40

Biosynth Carbosynth
2-Amino-3-(2-chlorobenzoyl)thiophene
250 mg
$ 397.50

Biosynth Carbosynth
2-Amino-3-(2-chlorobenzoyl)thiophene
100 mg
$ 219.00

Biosynth Carbosynth
2-Amino-3-(2-chlorobenzoyl)thiophene
50 mg
$ 120.50

Biosynth Carbosynth
2-Amino-3-(2-chlorobenzoyl)thiophene
500 mg
$ 720.00

Total 13 raw suppliers

Chemical Property of 2-Amino-3-(2-chlorobenzoyl)thiophene

Chemical Property:

Vapor Pressure:1.29E-07mmHg at 25°C
Melting Point:137-139℃
Refractive Index:1.664
Boiling Point:430.5 °C at 760 mmHg
Flash Point:214.2 °C
PSA：71.33000
Density:1.388 g/cm³
LogP:3.79590
Solubility.:Dichloromethane, Ethyl Acetate, Methanol
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:237.0015127
Heavy Atom Count:15
Complexity:249

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-3-(2-chlorobenzoyl)thiophene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)C2=C(SC=C2)N)Cl
Uses 2-Amino-3-(2-chlorobenzoyl)thiophene is a useful compound for the synthetic process of Brotizolam (B689280(M)), which is a hypnotic and a sedative.

Technology Process of 2-Amino-3-(2-chlorobenzoyl)thiophene

There total 4 articles about 2-Amino-3-(2-chlorobenzoyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 40018-26-6
1,4-dithiane-2,5-diol

: 40018-25-5
2-Chlorobenzoyl acetonitrile

: 40017-58-1
2-Amino-3-(o-chlorobenzoyl)-thiophene

Guidance literature:: With triethylamine; In 1,4-dioxane;
DOI:10.3987/COM-90-5442

Reference yield: 49.0%

: 36811-56-0
2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

: 40017-58-1
2-Amino-3-(o-chlorobenzoyl)-thiophene

: 36811-58-2
5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e][4,1]diazepin-2-one

Guidance literature:: With acetic acid; for 0.25h; Further byproducts given; Heating;
DOI:10.1135/cccc19840621

Reference yield:

: 53265-13-7
3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene

: 40017-58-1
2-Amino-3-(o-chlorobenzoyl)-thiophene

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / hydrazine hydrate / methanol; CHCl₃; H₂O / 1) 45 deg C, 10 min, 2) 60 deg C, 1,5 h, 3) standing overnight

2: 44 percent / acetic acid / benzene; pyridine / 5.5 h / Heating

With hydrazine hydrate; acetic acid; In pyridine; methanol; chloroform; water; benzene;
DOI:10.1135/cccc19840621