N-Boc-3-amino-2-formylthiophene

Base Information

• Chemical Name: N-Boc-3-amino-2-formylthiophene
• CAS No.: 368442-47-1
• Molecular Formula: C10H13NO3S
• Molecular Weight: 227.284
• Mol file: 368442-47-1.mol

Synonyms:(2-Formyl-thiophen-3-yl)-carbamic acid tert-butyl ester;(2-formylthiophen-3-yl)carbamic acid tert-butyl ester;

Chemical Property of N-Boc-3-amino-2-formylthiophene

Chemical Property:

• Refractive Index: n20/D1.561
• Flash Point: >110℃
• PSA: 83.64000
• Density: 1.186 g/mL at 25 °C
• LogP: 2.98060

Purity/Quality:

98%, ^*data from raw suppliers

tert-ButylN-(2-Formylthiophen-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

Useful:

Technology Process of N-Boc-3-amino-2-formylthiophene

There total 3 articles about N-Boc-3-amino-2-formylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 3-thienylcarbamate (19228-91-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(tert-butoxycarbonylamino)-2-thiophenecarboxaldehyde (368442-47-1)

Guidance literature:

tert-butyl 3-thienylcarbamate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

Reference yield: 100.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(tert-butoxycarbonylamino)-2-thiophenecarboxaldehyde (368442-47-1)

Guidance literature:

tert-butyl 3-thienylcarbamate; With n-butyllithium; In tetrahydrofuran; hexane; water; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

Reference yield: 73.0%

C12H18N2O4S → 3-(tert-butoxycarbonylamino)-2-thiophenecarboxaldehyde (368442-47-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃;

DOI:10.1021/jo070460b

upstream raw materials:

tert-butyl 3-thienylcarbamate

N,N-dimethyl-formamide

Downstream raw materials:

thieno<3,2-b>pyrrole-5-carboxylic acid methyl ester

Refernces

• 1、 -. "NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND". Page/Page column 66. . Retrieved 2008/06/13.
• 2、 Whittamore, Paul R.O.,Addie, Matthew S.,Bennett, Stuart N.L.,Birch, Alan M.,Butters, Michael,Godfrey, Linda,Kenny, Peter W.,Morley, Andrew D.,Murray, Paul M.,Oikonomakos, Nikos G.,Otterbein, Ludovic R.,Pannifer, Andrew D.,Parker, Jeremy S.,Readman, Kristy,Siedlecki, Pawel S.,Schofield, Paul,Stocker, Andy,Taylor, Melvyn J.,Townsend, Linda A.,Whalley, David P.,Whitehouse, Jennifer. "Novel thienopyrrole glycogen phosphorylase inhibitors: Synthesis, in vitro SAR and crystallographic studies". . p. 5567 - 5571. Retrieved 2007/10/03.