(S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-aMinopropanoate

Base Information

• Chemical Name: (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-aMinopropanoate
• CAS No.: 369648-61-3
• Molecular Formula: C19H20N4O2
• Molecular Weight: 336.393
• Mol file: 369648-61-3.mol

Synonyms:ethyl-(2S)-2-amino-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]propanoate;ethyl-(2-morpholin-4-yl-5,7-dihydro-thieno[3,4-d]pyrimidin-4-yl)-amine;

Chemical Property of (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-aMinopropanoate

Chemical Property:

• PSA: 90.13000
• LogP: 3.57960

Purity/Quality:

≥95% ^*data from raw suppliers

(S)-ethyl3-(4-(2,7-naphthyridin-1-ylamino)phenyl)-2-aminopropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-aMinopropanoate

There total 2 articles about (S)-ethyl 3-(4-(2,7-naphthyridin-1-ylaMino)phenyl)-2-aMinopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-(2S)-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]-2-[(t-butoxycarbonyl)amino]propanoate (369648-62-4) → ethyl-(2S)-2-amino-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]propanoate (369648-61-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

1-chloro-[2,7]naphthyridine (69042-30-4) + (S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester (67630-01-7) → ethyl-(2S)-2-amino-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]propanoate (369648-61-3) + ethyl-(2S)-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]-2-[(t-butoxycarbonyl)amino]propanoate (369648-62-4)

Guidance literature:

In 2-ethoxy-ethanol; at 100 - 120 ℃; for 1.25h;

Reference yield: 73.0%

1-keto-3-hydroxyspiro[3.5]-non-2-ene (15546-27-7) + ethyl-(2S)-2-amino-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]propanoate (369648-61-3) → UC(933)B1194 (455264-29-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

upstream raw materials:

1-chloro-[2,7]naphthyridine

(S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester

ethyl-(2S)-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]-2-[(t-butoxycarbonyl)amino]propanoate

Downstream raw materials:

UC⁽⁹³³⁾B₁₁₉₄