69042-30-4

Basic information

• Product Name: 2,7-NAPHTHYRIDINE, 1-CHLORO-
• Synonyms: 1-CHLORO-2,7-NAPHTHYRIDINE;2,7-NAPHTHYRIDINE, 1-CHLORO-;1-Chlorocopyrine;1-Chloro-[2,7]naphthyridi...
• CAS NO: 69042-30-4
• Molecular Formula: C₈H₅ClN₂
• Molecular Weight: 164.594
• Product Categories: Non-Chiral heterocyclic compounds;Heterocycle-Pyridine series
• Mol File: 69042-30-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 326.4 °C at 760 mmHg
• Flash Point: 181.1 °C
• Appearance: /
• Density: 1.349
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.52±0.30(Predicted)
• CAS DataBase Reference: 2,7-NAPHTHYRIDINE, 1-CHLORO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-NAPHTHYRIDINE, 1-CHLORO-(69042-30-4)
• EPA Substance Registry System: 2,7-NAPHTHYRIDINE, 1-CHLORO-(69042-30-4)

Safety Data

• Hazardous Substances Data: 69042-30-4(Hazardous Substances Data)

Usage

General Description

1-chloro-2,7-naphthyridine, also known as CAS No. 6708-30-1, is a chemical compound that belongs to the class of organic compounds known as naphthyridines. It is used as a useful pharmaceutical intermediate. Naphthyridines are compounds containing a naphthyridine moiety, which is a polycyclic aromatic compound made up of two benzene rings fused to a pyridine ring. With the formula C8H5ClN2, its exact mass is 162.009491, and its molecular weight is 162.592. It appears as a white to off-white crystalline powder. It's considered stable under normal temperatures and pressures. However, no recommended handling advice or safety protocol is given; as with all chemicals, it should be handled with care and proper protection.

Upstream product

• 497-19-8 sodium carbonate 
• 67988-50-5 1-hydroxy-2,7-naphthyridine 
• 950746-11-9 4-[2-pyrrolidin-1-ylvinyl]nicotinonitrile 
• 950746-19-7 2,7-naphthyridin-1-ol hydrobromide 
• 369648-60-2 1-hydroxy-[2,7]-naphthyridine hydrochloride salt 
• 517-40-8 4-methyl-2,3-pyridinedicarboxylic acid 
• 853648-79-0 4-(2-hydroxy-ethyl)-nicotinic acid amide 
• 6790-32-5 3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one 
• 3222-50-2 4-methylnicotinic acid 
• 67988-50-5 2,7-naphthyridinyl-1(2H)-one 

Downstream Products

• 253-45-2 [2,7]naphthyridine 
• 27225-00-9 2,7-naphthyridin-1-ylamine 
• 455264-29-6 UC⁽⁹³³⁾B₁₁₉₄ 
• 455264-30-9 zaurategrast ethyl 
• 369648-61-3 ethyl-(2S)-2-amino-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]propanoate 
• 369648-62-4 ethyl-(2S)-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]-2-[(t-butoxycarbonyl)amino]propanoate 

Relevant articles and documents

Preparation method of formaldehyde-substituted aza-condensed ring compound

The invention provides a preparation method of a formaldehyde-substituted aza-condensed ring compound, comprising the following steps: by using an aza-condensed ring lactam compound as a starting material, carrying out halogenation reaction, methylation reaction and methyl oxidation reaction to obtain the formaldehyde-substituted aza-condensed ring compound. According to the preparation method ofthe formaldehyde-substituted aza-condensed ring compound, the whole synthesis route is good in step repeatability, mild in operation condition and high in safety, and large-scale production and industrial popularization are facilitated; post-treatment energy consumption is low, a large amount of toxic wastewater is not generated, no pollution is caused to the environment, the production safety level and the production cost are reduced, application of green and environment-friendly industrial production is facilitated, and wide application prospects are achieved.

Process for Preparing 1-Halo-2,7-Naphthyridinyl Derivatives

A process for preparing 1-halo-2,7-naphthyridinyl derivatives is described (I), wherein X is Cl or Br; which process comprises the following steps: (i) reaction of a 3-cyano-4-methylpyridine derivative of formula (A): with a compound of formula (II), in the presence of an N,N-dimethylformamide diC1-6alkylacetal; to give an enamine derivative of formula (III), (ii) cyclisation of the enamine of formula (III), to obtain the compound of formula (IV), (iii) reaction of the compound of formula (IV) with a halogenating agent, to obtain a compound of formula (I).

PROCESS FOR THE PREPARATION OF PHENYLALANINE ENAMIDE DERIVATIVES

A process for the preparation of a class of phenylalanine enamide derivatives is described formula (1) wherein: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a linker group selected from -N(R4)- [where R4 is a hydrogen atom or an optionally substituted straight or branched C1-6alkyl group], -CON(R4)-, or -S(O)2N(R4)-; R1 is a carboxylic acid (-CO2H) or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; Rx, Ry and Rz which may be the same or different is each an atom or group -L1(Alk1)n(R3)v; and the salts, solvates, hydrates and N-oxides thereof; which comprises reacting a compound of formula (2): wherein: Qa is a group -N(R4)H; and the salts, solvates, hydrates and N-oxides thereof; with a compound Ar1W wherein W is a group selected from X1 (wherein X1 is a leaving atom or group), -COX2 (wherein X2 is a halogen atom or a -OH group) or -SO2 X3 (in which X3 is a halogen atom).