2,4-Undecadiene-8,10-diynamide, N-(2-phenylethyl)-, (E,E)-

Base Information

• Chemical Name: 2,4-Undecadiene-8,10-diynamide, N-(2-phenylethyl)-, (E,E)-
• CAS No.: 37064-11-2
• Molecular Formula: C₁₉H₁₉NO
• Molecular Weight: 277.366
• Mol file: 37064-11-2.mol

Synonyms:

Chemical Property of 2,4-Undecadiene-8,10-diynamide, N-(2-phenylethyl)-, (E,E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Undecadiene-8,10-diynamide, N-(2-phenylethyl)-, (E,E)-

There total 6 articles about 2,4-Undecadiene-8,10-diynamide, N-(2-phenylethyl)-, (E,E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pent-1-yn-5-ol (5390-04-5) → (E,E)-2,4-undecadien-8,10-diynoic acid phenethylamide (37064-11-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: potassium hydroxide / methanol; water / 0 °C

1.2: 3 h / 20 °C

2.1: piperidine; copper(l) chloride / 0.5 h / 0 - 20 °C

3.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 1 h / -78 °C

3.2: 1.33 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

4.2: 1 h / 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C

6.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 1 h / -78 °C

6.2: 1.33 h / 20 °C

7.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

7.2: 1 h / 0 - 20 °C

8.1: sodium hydroxide / 24 h / 20 °C

9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

With piperidine; oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

5-iodo-4-pentyn-1-ol (94230-39-4) → (E,E)-2,4-undecadien-8,10-diynoic acid phenethylamide (37064-11-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: piperidine; copper(l) chloride / 0.5 h / 0 - 20 °C

2.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 1 h / -78 °C

2.2: 1.33 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

3.2: 1 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C

5.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 1 h / -78 °C

5.2: 1.33 h / 20 °C

6.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

6.2: 1 h / 0 - 20 °C

7.1: sodium hydroxide / 24 h / 20 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

With piperidine; oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

7-(trimethylsilyl)hepta-4,6-diyn-1-ol (83670-22-8) → (E,E)-2,4-undecadien-8,10-diynoic acid phenethylamide (37064-11-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 1 h / -78 °C

1.2: 1.33 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

2.2: 1 h / 20 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -78 °C

4.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 1 h / -78 °C

4.2: 1.33 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

5.2: 1 h / 0 - 20 °C

6.1: sodium hydroxide / 24 h / 20 °C

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

With oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

3-bromopropiolic acid

4-pentyn-1-al

phenethylamine

pent-1-yn-5-ol