2H-Thiopyran-4-ol, 4-(4-amino-2,6-difluorophenyl)tetrahydro-

Base Information

Chemical Name:2H-Thiopyran-4-ol, 4-(4-amino-2,6-difluorophenyl)tetrahydro-
CAS No.:371195-40-3
Molecular Formula:C11H13F2NOS
Molecular Weight:245.293
Hs Code.:
Mol file:371195-40-3.mol

Synonyms:4-(4-amino-2,6-difluorophenyl)tetrahydro-2H-thiopyran-4-ol;4-(4-Amino-2,6-difluoro-phenyl)-tetrahydro-thiopyran-4-ol;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-Thiopyran-4-ol, 4-(4-amino-2,6-difluorophenyl)tetrahydro-

Chemical Property:

Boiling Point:411.2±45.0 °C(Predicted)
PSA：71.55000
Density:1.391±0.06 g/cm3(Predicted)
LogP:2.84280

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2H-Thiopyran-4-ol, 4-(4-amino-2,6-difluorophenyl)tetrahydro-

There total 4 articles about 2H-Thiopyran-4-ol, 4-(4-amino-2,6-difluorophenyl)tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 371195-40-3
4-(4-amino-2,6-difluorophenyl)-tetrahydrothiopyran-4-ol

Guidance literature:: 4-chloro-3,5-difluorobenzenamine; With n-butyllithium; In tetrahydrofuran; at -78 - -70 ℃; for 6.5h;

Tetrahydrothiopyran-4-one; In tetrahydrofuran; at -70 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 372-39-4
3,5-difluoroaniline

: 371195-40-3
4-(4-amino-2,6-difluorophenyl)-tetrahydrothiopyran-4-ol

Guidance literature:: 3,5-difluoroaniline; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 - -65 ℃; for 0.75h;

With chloro-trimethyl-silane; In tetrahydrofuran; hexanes; at -65 - 20 ℃;

Tetrahydrothiopyran-4-one; With n-butyllithium; more than 3 stages;

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 149524-30-1
1-(3,5-difluorophenyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane

: 371195-40-3
4-(4-amino-2,6-difluorophenyl)-tetrahydrothiopyran-4-ol

Guidance literature:: 1-(3,5-difluorophenyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

Tetrahydrothiopyran-4-one; In tetrahydrofuran; hexane; at 20 ℃; for 18h;

With water; In tetrahydrofuran; hexane;