2-Phenyl-1H-pyrrolo[3,2-C]pyridine

Base Information

• Chemical Name: 2-Phenyl-1H-pyrrolo[3,2-C]pyridine
• CAS No.: 37388-07-1
• Molecular Formula: C13H10N2
• Molecular Weight: 194.236
• DSSTox Substance ID: DTXSID10570082
• Nikkaji Number: J747.047I
• Wikidata: Q82457413
• Mol file: 37388-07-1.mol

Synonyms:2-PHENYL-1H-PYRROLO[3,2-C]PYRIDINE;37388-07-1;1H-Pyrrolo[3,2-c]pyridine, 2-phenyl-;SCHEMBL8878252;DTXSID10570082;COOUBAOIGZXDFV-UHFFFAOYSA-N

Chemical Property of 2-Phenyl-1H-pyrrolo[3,2-C]pyridine

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 194.084398327
• Heavy Atom Count: 15
• Complexity: 211

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC3=C(N2)C=CN=C3

Technology Process of 2-Phenyl-1H-pyrrolo[3,2-C]pyridine

There total 26 articles about 2-Phenyl-1H-pyrrolo[3,2-C]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-amino-3-(2-phenylethynyl)pyridine (449173-31-3) → 2-phenyl-1H-pyrrolo[3,2-c]pyridine (37388-07-1)

Guidance literature:

With sodium hydrogencarbonate; In water; at 200 ℃; for 1.5h; Microwave irradiation;

DOI:10.1016/j.tet.2010.06.083

Reference yield: 91.0%

4-nitro-3-(2-phenylethenyl)pyridine N-oxide (54629-90-2) → 2-phenyl-1H-pyrrolo[3,2-c]pyridine (37388-07-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,10-Phenanthroline; carbon monoxide; In acetonitrile; at 120 ℃; for 22h; under 4560.31 Torr;

DOI:10.1016/j.tet.2010.01.029

Reference yield: 60.0%

N-{3-[(E)-2-phenylethenyl]pyridin-4-yl}hydroxylamine (627511-08-4) → 2-phenyl-1H-pyrrolo[3,2-c]pyridine (37388-07-1)

Guidance literature:

N-{3-[(E)-2-phenylethenyl]pyridin-4-yl}hydroxylamine; With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In water; acetic acid; acetonitrile; at 0 ℃;

With iron; acetic acid; In ethanol; Heating;

DOI:10.1055/s-2003-40884

upstream raw materials:

N-{3-[(E)-2-phenylethenyl]pyridin-4-yl}hydroxylamine

3-methyl-4-nitropyridine N-oxide

4-nitro-3-styrylpyridine 1-oxide

4-nitro-3-[(E)-2-phenylethenyl]pyridine