3-(2,6-Dimethoxy-4-methylphenyl)acrylic acid

Base Information

Chemical Name:3-(2,6-Dimethoxy-4-methylphenyl)acrylic acid
CAS No.:6334-49-2
Molecular Formula:C12H14O4
Molecular Weight:222.2372
Hs Code.:
DSSTox Substance ID:DTXSID10283009

Synonyms:3-(2,6-dimethoxy-4-methylphenyl)prop-2-enoic acid;6334-49-2;3-(2,6-dimethoxy-4-methylphenyl)acrylic acid;NCIStruc1_000572;NCIStruc2_000407;DTXSID10283009;NCI60_002392

Suppliers and Price of 3-(2,6-Dimethoxy-4-methylphenyl)acrylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 3-(2,6-Dimethoxy-4-methylphenyl)acrylic acid

Chemical Property:

Vapor Pressure:9.23E-07mmHg at 25°C
Boiling Point:389.4°Cat760mmHg
Flash Point:150°C
Density:1.173g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:222.08920892
Heavy Atom Count:16
Complexity:248

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C(=C1)OC)C=CC(=O)O)OC

Technology Process of 3-(2,6-Dimethoxy-4-methylphenyl)acrylic acid

There total 3 articles about 3-(2,6-Dimethoxy-4-methylphenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 6937-96-8
2,6-dimethoxy-4-methylbenzaldehyde

: 1530-45-6
(carbethoxymethyl)triphenylphosphonium bromide

: 6334-49-2
3-(2,6-dimethoxy-4-methylphenyl)acrylic acid

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2006.09.034

Reference yield:

: 4179-19-5
1,3-dimethoxy-5-methylbenzene

: 6334-49-2
3-(2,6-dimethoxy-4-methylphenyl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: butyl lithium; diethyl ether / anschliessend mit N-Methyl-formanilid und Behandeln des Reaktionsgemisches mit Eis und wss. HCl

2: pyridine; piperidine

With piperidine; pyridine; n-butyllithium; diethyl ether;
DOI:10.1021/ja01243a018