Technology Process of 1H-Indole, 1-(1,1-dimethyl-2-propenyl)-
There total 1 articles about 1H-Indole, 1-(1,1-dimethyl-2-propenyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 2-methylbut-3-en-2-yl carbonate; tricarbonyl(η(6)-indole)chromium(0);
With
4,5-bis-(di-tert-butyl-phosphanyl)-9,9-dimethyl-9H-xanthene; bis(μ-chloro)bis{(1,2,3-η)-3-methyl-2-butenyl}palladium; caesium carbonate;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
acetonitrile;
at 0 ℃;
Overall yield = 86 %; Overall yield = 39.9 mg; regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol4011344
- Guidance literature:
-
2,5-Dichloro-1,4-benzoquinone; 1-(2-methylbut-3-en-2-yl)-1H-indole;
With
hydrogenchloride;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
Further stages.;
DOI:10.1039/b712227f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: POCl3 / 20 °C
1.2: 100 percent / aq. NaOH / 50 °C
2.1: K2CO3; K3Fe(CN)6; (DHQD)2PYR / K2[OsO2(OH)4] / 2-methyl-propan-2-ol; H2O / 4 °C
3.1: TsCl; Et3N; Me3N*HCl / CH2Cl2 / 0 °C
4.1: 83 percent / NaH / tetrahydrofuran / 0 - 20 °C
5.1: 36 percent / aq. NaOH; t-BuOCl; (DHQD)2AQN / K2[OsO2(OH)4] / propan-1-ol; H2O / 20 °C
With
sodium hydroxide; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; hydroquinidine anthraquinone-1,4-diyl diether; tert-butylhypochlorite; trimethylamine hydrochloride; sodium hydride; potassium carbonate; triethylamine; p-toluenesulfonyl chloride; potassium hexacyanoferrate(III); trichlorophosphate;
K2;
In
tetrahydrofuran; propan-1-ol; dichloromethane; water; tert-butyl alcohol;
1.1: Vilsmeier formylation / 2.1: Sharpless asymmetric dihydroxylation / 4.1: Horner-Emmons reaction / 5.1: Sharpless asymmetric reaction;
DOI:10.1016/S0040-4039(02)00607-X
