Benzenepropanamine, 3-fluoro-2-methyl-, acetate

Base Information

• Chemical Name: Benzenepropanamine, 3-fluoro-2-methyl-, acetate
• CAS No.: 377083-85-7
• Molecular Formula: C10H14FN.C2H4O2
• Molecular Weight: 227.279
• Hs Code.: 2921499090
• Mol file: 377083-85-7.mol

Synonyms:3-(2-methyl-3-fluorophenyl)-1-propylamine,AcOH salt;2-Thiophenethiol,3-(2-methyl-3-benzofuranyl);3-(2-methyl-3-benzofuryl)-2-thiophenethiol;

Chemical Property of Benzenepropanamine, 3-fluoro-2-methyl-, acetate

Chemical Property:

• PSA: 63.32000
• LogP: 2.81660

Purity/Quality:

3-(3-Fluoro-2-methylphenyl)propan-1-amine acetic acid salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanamine, 3-fluoro-2-methyl-, acetate

There total 6 articles about Benzenepropanamine, 3-fluoro-2-methyl-, acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

C10H12FN3 (377083-83-5) → 3-(2-methyl-3-fluorophenyl)-1-propylamine, AcOH salt (377083-85-7)

Guidance literature:

With hydrogen; acetic acid; palladium hydroxide/carbon; In ethanol; for 30h;

Reference yield:

3-fluoro-2-methylcinnamic acid (155814-23-6) → 3-(2-methyl-3-fluorophenyl)-1-propylamine, AcOH salt (377083-85-7)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / palladium hydroxide/carbon / ethanol / 22 h

2: lithium aluminium tetrahydride / tetrahydrofuran / 1.17 h / 0 °C

3: triethylamine / tetrahydrofuran / 0.17 h / 0 °C

4: sodium azide; tetra(n-butyl)ammonium hydrogensulfate / dimethyl sulfoxide / 16 h / 45 °C

5: hydrogen; acetic acid / palladium hydroxide/carbon / ethanol / 30 h

With lithium aluminium tetrahydride; sodium azide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; triethylamine; palladium hydroxide/carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

Reference yield:

C10H13FO (377083-81-3) → 3-(2-methyl-3-fluorophenyl)-1-propylamine, AcOH salt (377083-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C

2: sodium azide; tetra(n-butyl)ammonium hydrogensulfate / dimethyl sulfoxide / 16 h / 45 °C

3: hydrogen; acetic acid / palladium hydroxide/carbon / ethanol / 30 h

With sodium azide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; triethylamine; palladium hydroxide/carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

upstream raw materials:

C₁₀H₁₂FN₃

3-fluoro-2-methylcinnamic acid

C₁₀H₁₃FO

C₁₀H₁₁FO₂

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