3-Bromo-2-hydroxy-5-methoxybenzaldehyde

Base Information

• Chemical Name: 3-Bromo-2-hydroxy-5-methoxybenzaldehyde
• CAS No.: 50343-02-7
• Molecular Formula: C8H7BrO3
• Molecular Weight: 231.046
• Hs Code.: 2913000090
• European Community (EC) Number: 622-189-4
• DSSTox Substance ID: DTXSID90352843
• Wikidata: Q82130233
• Mol file: 50343-02-7.mol

Synonyms:3-bromo-2-hydroxy-5-methoxybenzaldehyde;50343-02-7;3-Bromo-2-hydroxy-5-methoxybenzenecarbaldehyde;3-bromo-2-hydroxy-5-methoxy-benzaldehyde;SCHEMBL931983;DTXSID90352843;BSLKYCQDKAAGGV-UHFFFAOYSA-N;MFCD00091938;STL405615;AKOS000112590;BP-11734;CS-0206153;FT-0639893;EN300-68557;9P-948;A828079;AE-848/30539040;J-511868;Z274774402

Chemical Property of 3-Bromo-2-hydroxy-5-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00354mmHg at 25°C
• Melting Point: 108-110°C
• Boiling Point: 272.9°C at 760 mmHg
• Flash Point: 118.9°C
• PSA: 46.53000
• Density: 1.653g/cm³
• LogP: 1.97580
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 229.95786
• Heavy Atom Count: 12
• Complexity: 162

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-2-hydroxy-5-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)Br)O)C=O

Technology Process of 3-Bromo-2-hydroxy-5-methoxybenzaldehyde

There total 7 articles about 3-Bromo-2-hydroxy-5-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) → 3-Bromo-2-hydroxy-5-methoxy-benzaldehyde (50343-02-7)

Guidance literature:

With bromine; sodium acetate; In acetic acid; at 20 ℃; for 1h;

DOI:10.1021/ol036284k

Reference yield: 35.0%

5-methoxysalicylic acid (2612-02-4) → 3-Bromo-2-hydroxy-5-methoxy-benzaldehyde (50343-02-7)

Guidance literature:

With bromine; In chloroform; at 0 - 20 ℃; for 5h;

Reference yield: 35.0%

4-methoxymethylsalicylate (5446-02-6) → 3-Bromo-2-hydroxy-5-methoxy-benzaldehyde (50343-02-7)

Guidance literature:

With bromine; In chloroform;

upstream raw materials:

2-hydroxy-5-methoxybenzaldehyde

bromine

sodium acetate

acetic acid

Downstream raw materials:

3-bromo-2,5-dimethoxybenzaldehyde

N-(3-bromo-5-methoxysalicylidene)-3-[bis(5-methyl-2-furyl)methyl]aniline