2-[2-(3-Chloro-2-methylanilino)phenyl]acetic acid

Base Information

Chemical Name:2-[2-(3-Chloro-2-methylanilino)phenyl]acetic acid
CAS No.:37984-36-4
Molecular Formula:C15H14ClNO2
Molecular Weight:275.73000
Hs Code.:
ChEMBL ID:CHEMBL77576
DSSTox Substance ID:DTXSID50877724
Nikkaji Number:J341.685B
Wikidata:Q82859571
Mol file:37984-36-4.mol

Synonyms:CHEMBL77576;37984-36-4;SCHEMBL7164972;DTXSID50877724;BDBM50228741;PHENYLACETIC ACID,2-(2'-ME-3'-CL)ANILINO;2-[(3-Chloro-2-methylphenyl)amino]benzeneacetic acid

Suppliers and Price of 2-[2-(3-Chloro-2-methylanilino)phenyl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-[2-(3-Chloro-2-methylanilino)phenyl]acetic acid

Chemical Property:

PSA：49.33000
LogP:4.09210
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:275.0713064
Heavy Atom Count:19
Complexity:311

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC=C1Cl)NC2=CC=CC=C2CC(=O)O

Technology Process of 2-[2-(3-Chloro-2-methylanilino)phenyl]acetic acid

There total 6 articles about 2-[2-(3-Chloro-2-methylanilino)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-80-5
2-ethoxy-ethanol

: 37984-35-3
sodium salt of [o-(3-chloro-o-toluidino)-phenyl]-glyoxylic acid

: 37984-36-4
2-[(2-methyl-3-chlorophenyl)amino]phenylacetic Acid

Guidance literature:: With sodium methylate; hydrazine hydrate; In ethanol; water;

Reference yield:

: 749146-99-4
[2-(3-Chloro-2-methyl-phenylamino)-phenyl]-oxo-acetic acid

: 37984-36-4
2-[(2-methyl-3-chlorophenyl)amino]phenylacetic Acid

Guidance literature:: With sodium methylate; hydrazine hydrate; In 2-methoxy-ethanol; Yield given; 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h;
DOI:10.1021/jm00171a008

Reference yield:

: 37984-34-2
1-(3-Chlor-o-tolyl)-indol-2,3-dion

: 37984-36-4
2-[(2-methyl-3-chlorophenyl)amino]phenylacetic Acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1 N NaOH / ethanol; H₂O / 0.17 h / Heating

2: hydrazine hydrate, NaOCH₃ / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h

With sodium hydroxide; sodium methylate; hydrazine hydrate; In ethanol; 2-methoxy-ethanol; water;
DOI:10.1021/jm00171a008