Carbamic acid, [3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl ]-2-propynyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl ]-2-propynyl]-, 1,1-dimethylethyl ester
CAS No.:383433-14-5
Molecular Formula:C29H29N5O3
Molecular Weight:495.581
Hs Code.:
Mol file:383433-14-5.mol

Synonyms:

Suppliers and Price of Carbamic acid, [3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl ]-2-propynyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbamic acid, [3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl ]-2-propynyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl ]-2-propynyl]-, 1,1-dimethylethyl ester

There total 11 articles about Carbamic acid, [3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl ]-2-propynyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 537705-10-5
(6-iodoquinazolin-4-yl)-[3-methyl-4-(6-methylpyridin-3-yloxy)phenyl]amine hydrochloride

: 92136-39-5
N-tert-Butoxycarbonyl-1-amino-3-propyne

: 383433-14-5
(3-{4-[3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino]quinazolin-6-yl}prop-2-ynyl)carbamic acid tert-butyl ester

Guidance literature:: With diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 98556-31-1
4-chloro-6-iodoquinazoline

: 383433-14-5
(3-{4-[3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino]quinazolin-6-yl}prop-2-ynyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 3 h / 22 - 23 °C / Inert atmosphere; Large scale; Green chemistry

2: ethyl acetate; toluene; tert-butyl alcohol; 1,2-dichloro-ethane / 3 h / 26 °C / Inert atmosphere; Large scale

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; diisopropylamine; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/op050039u

Reference yield:

: 92136-39-5
N-tert-Butoxycarbonyl-1-amino-3-propyne

: 383433-14-5
(3-{4-[3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino]quinazolin-6-yl}prop-2-ynyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 3 h / 22 - 23 °C / Inert atmosphere; Large scale; Green chemistry

2: ethyl acetate; toluene; tert-butyl alcohol; 1,2-dichloro-ethane / 3 h / 26 °C / Inert atmosphere; Large scale

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; diisopropylamine; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/op050039u