Pyridine, 2,4,5-triphenyl-

Base Information

• Chemical Name: Pyridine, 2,4,5-triphenyl-
• CAS No.: 38537-90-5
• Molecular Formula: C23H17N
• Molecular Weight: 307.395
• Mol file: 38537-90-5.mol

Synonyms:

Chemical Property of Pyridine, 2,4,5-triphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyridine, 2,4,5-triphenyl-

There total 10 articles about Pyridine, 2,4,5-triphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,3-diphenyl-1,3-butadiene (2548-47-2) + benzonitrile (100-47-0) → 2,4,5-triphenylpyridine (38537-90-5)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tricyclohexylphosphine; In toluene; at 130 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja208162w

Reference yield: 57.0%

2,3-diphenyl-1,4-diiodo-1,3-diene (1052692-43-9) + benzonitrile (100-47-0) → 2,4,5-triphenylpyridine (38537-90-5)

Guidance literature:

2,3-diphenyl-1,4-diiodo-1,3-diene; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 1h; Inert atmosphere;

With N,N,N,N,N,N-hexamethylphosphoric triamide; In diethyl ether; pentane; at 20 ℃; for 0.5h; Inert atmosphere;

benzonitrile; In diethyl ether; pentane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.200701742

Reference yield:

2,3-diphenyl-1,3-butadiene (2548-47-2) + benzonitrile (100-47-0) → 2,4,5-triphenylpyridine (38537-90-5) + 3,4,6-triphenyl-1,2,3,4-tetrahydropyridine + 3,4,6-triphenyl-1,2-dihydropyridine (1345015-21-5) + 3,4,6-triphenyl-2,5-dihydropyridine (1345015-20-4)

Guidance literature:

2,3-diphenyl-1,3-butadiene; benzonitrile; With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tricyclohexylphosphine; In benzene-d6; at 20 ℃; for 3h; Inert atmosphere;

With carbon monoxide; In benzene-d6; at 20 ℃; for 84h; under 3800.26 Torr;

DOI:10.1021/ja208162w

upstream raw materials:

2-bromo-3,4,6-triphenyl-pyridine

benzalacetophenone

2,3-diphenyl-1,4-diiodo-1,3-diene

benzonitrile

Refernces

• 1、 Ohashi, Masato,Takeda, Ippei,Ikawa, Masashi,Ogoshi, Sensuke. "Nickel-catalyzed dehydrogenative [4 + 2] cycloaddition of 1,3-dienes with nitriles". supporting information; experimental part. p. 18018 - 18021. Retrieved 2011/12/13.
• 2、 Katritzky, Alan R.,Mazurkiewicz, Roman,Stevens, Christian V.,Gordeev, Mikhail F.. "A New and Safe Approach to (N-Vinylimino)phosphoranes". . p. 2740 - 2742. Retrieved 2007/10/02.