5-Thiazoleacetic acid, 2-[(triphenylmethyl)amino]-, methyl ester

Base Information

• Chemical Name: 5-Thiazoleacetic acid, 2-[(triphenylmethyl)amino]-, methyl ester
• CAS No.: 385785-17-1
• Molecular Formula: C25H22N2O2S
• Molecular Weight: 414.528
• Mol file: 385785-17-1.mol

Synonyms:

Chemical Property of 5-Thiazoleacetic acid, 2-[(triphenylmethyl)amino]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Thiazoleacetic acid, 2-[(triphenylmethyl)amino]-, methyl ester

There total 1 articles about 5-Thiazoleacetic acid, 2-[(triphenylmethyl)amino]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

trityl chloride (76-83-5) + (2-amino-thiazol-5-yl)acetic acid methyl ester (110295-93-7) → methyl [2-(tritylamino)-1,3-thiazol-5-yl]acetate (385785-17-1)

Guidance literature:

With triethylamine; In dichloromethane; water;

Reference yield: 88.0%

methyl [2-(tritylamino)-1,3-thiazol-5-yl]acetate (385785-17-1) → [2-(tritylamino)-1,3-thiazol-5-yl]acetic acid (385785-18-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 3h;

DOI:10.1021/jm050786h

Reference yield:

methyl [2-(tritylamino)-1,3-thiazol-5-yl]acetate (385785-17-1) → 2-(2-amino-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide (385785-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / aq. NaOH / ethanol; tetrahydrofuran / 3 h / 20 °C

2: 79 percent / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetra-Me-uronium PF₆(-); DIEA / dimethylformamide / 18 h / 50 °C

3: 83 percent / aq. TFA / 1 h

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm050786h

upstream raw materials:

trityl chloride

(2-amino-thiazol-5-yl)acetic acid methyl ester

Downstream raw materials:

[2-(tritylamino)-1,3-thiazol-5-yl]acetic acid

2-(2-amino-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide

2-(2-amino-1,3-thiazol-5-yl)-N-(2,3-difluorophenyl)acetamide

N-(3-fluorophenyl)-2-[2-(tritylamino)-1,3-thiazol-5-yl]acetamide

Refernces

• 1、 -. "QUINAZOLINE COMPOUNDS". Page 88. . Retrieved 2010/02/07.