2-Propenoyl chloride, 3-[4-(dimethylamino)phenyl]-

Base Information

• Chemical Name: 2-Propenoyl chloride, 3-[4-(dimethylamino)phenyl]-
• CAS No.: 39145-43-2
• Molecular Formula: C11H12ClNO
• Molecular Weight: 209.675
• Mol file: 39145-43-2.mol

Synonyms:3-(4-dimethylamino-phenyl)-acryloyl chloride;p-(dimethylamino)cinnamoyl chloride;2-Propenoyl chloride,3-[4-(dimethylamino)phenyl];4-dimethylaminocinnamoyl chloride;

Chemical Property of 2-Propenoyl chloride, 3-[4-(dimethylamino)phenyl]-

Chemical Property:

• PSA: 20.31000
• LogP: 2.53120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoyl chloride, 3-[4-(dimethylamino)phenyl]-

There total 2 articles about 2-Propenoyl chloride, 3-[4-(dimethylamino)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-dimethylaminocinnamic acid (1552-96-1) → p-(dimethylamino)cinnamoyl chloride (39145-43-2)

Guidance literature:

With phosgene; In water; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2019.02.074

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) → 4'-N,N-dimethylaminocinnamic acid chloride (39145-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; piperidine / 90 °C

2: oxalyl dichloride / dichloromethane / 20 °C

With piperidine; pyridine; oxalyl dichloride; In dichloromethane;

DOI:10.2174/1570180811666140812231519

Reference yield: 92.0%

p-(dimethylamino)cinnamoyl chloride (39145-43-2) + 2-chloro-ethanol (107-07-3) → 2'-chloroethyl 4-dimethylaminocinnamate (866404-56-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;

upstream raw materials:

4-dimethylaminocinnamic acid

4-dimethylamino-benzaldehyde

Downstream raw materials:

3-(4-dimethylamino-phenyl)-N-(5-nitro-thiazol-2-yl)-acrylamide

3-(4-dimethylamino-phenyl)-N-(4-phenyl-thiazol-2-yl)-acrylamide

3-(4-dimethylamino-phenyl)-1-naphtho[1,2-d]oxazol-2-yl-propenone

3,3'-bis-(4-dimethylamino-phenyl)-1,1'-benzo[1,2-d;4,5-d']bisoxazole-2,6-diyl-bis-propenone

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