2-Chloroethanol

Base Information

• Chemical Name: 2-Chloroethanol
• CAS No.: 107-07-3
• Deprecated CAS: 1867-09-0,1253945-55-9,1253945-55-9
• Molecular Formula: C2H5 Cl O
• Molecular Weight: 80.5141
• Hs Code.: 29333999
• European Community (EC) Number: 203-459-7
• ICSC Number: 0236
• NSC Number: 122289
• UN Number: 1135
• UNII: 753N66IHAN
• DSSTox Substance ID: DTXSID1021877
• Nikkaji Number: J4.050I
• Wikipedia: 2-Chloroethanol
• Wikidata: Q209354
• NCI Thesaurus Code: C122479
• Metabolomics Workbench ID: 51618
• ChEMBL ID: CHEMBL191244
• Mol file: 107-07-3.mol

Synonyms:2 Chlorethanol;2 Chloroethyl Alcohol;2-Chlorethanol;2-Chloroethyl Alcohol;Alcohol, 2-Chloroethyl;Chlorohydrin, Ethylene;Ethylene Chlorohydrin;Ethylenechlorhydrin

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 2-Chloroethanol

Chemical Property:

• Appearance/Colour: clear, colorless liquid.
• Vapor Pressure: 4.79mmHg at 25°C
• Melting Point: -63 ºC
• Refractive Index: n20/D 1.441(lit.)
• Boiling Point: 129 ºC
• Flash Point: 55 ºC
• PSA: 20.23000
• Density: 1.201
• LogP: 0.21750
• Water Solubility.: MISCIBLE
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 80.0028925
• Heavy Atom Count: 4
• Complexity: 10
• Transport DOT Label: Poison Inhalation Hazard Flammable Liquid

Purity/Quality:

Safty Information:

• Hazard Codes: T+:Very toxic
• Statements: R26/27/28:
• Safety Statements: S28A:; S45:; S7/9:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Other Toxic Gases & Vapors
• Canonical SMILES: C(CCl)O
• Inhalation Risk: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is severely irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system, cardiovascular system, kidneys and liver. This may result in cardiac disorders, low blood pressure, kidney impairment, liver impairment and respiratory failure. Exposure could cause death.

Technology Process of 2-Chloroethanol

There total 153 articles about 2-Chloroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

2-(benzylthio)ethanol (3878-41-9) → dibenzyl disulphide (150-60-7) + dibenzyl sulfide (538-74-9) + benzyl chloride (100-44-7) + 2-chloro-ethanol (107-07-3)

Guidance literature:

iron(III) chloride; In carbon disulfide; for 40h; Ambient temperature;

Reference yield:

bromosulfurous acid-(2-chloro-ethyl ester) (835909-18-7) + water (7732-18-5) → hydrogen bromide (10035-10-6,12258-64-9) + 2-chloro-ethanol (107-07-3)

Guidance literature:

Hydrolysis;

Reference yield:

C13H16ClN3O3 → succinic acid (110-15-6) + benzylamine (100-46-9) + 2-chloro-ethanol (107-07-3) + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

With phosphate buffer; sodium chloride; at 70 ℃; pH=7.0; Kinetics;

DOI:10.1021/tx950155y

upstream raw materials:

oxirane

ethylmagnesium chloride

1,4-dioxane

sodium 2-hydroxyethoxide

Downstream raw materials:

1,4-bis(2-hydroxyethyl)piperazine

2-(2,5-dimethyl-pyrrolidino)-ethanol

chloromaleic acid bis-(2-chloro-ethyl ester)

N-Carbamoyl-maleinsaeure-<2-chlor-ethylester>-amid

Refernces

• 1、 Jirkovsky, Jakub S.,Busch, Michael,Ahlberg, Elisabet,Panas, Itai,Krtil, Petr. "Switching on the electrocatalytic ethene epoxidation on nanocrystalline RuO2". . p. 5882 - 5892. Retrieved 2011.
• 2、 Grunwald, Ernest. "Reaction Mechanism from Structure-Energy Relations. 2. Acid-Catalyzed Addition of Alcohols to Formaldhyde". . p. 4715 - 4720. Retrieved 1985.
• 3、 Brundrett, Robert B.. "Chemistry of Nitrosoureas. Intermediacy of 4,5-Dihydro-1,2,3-oxadiazole in 1,3-Bis(2-chloroethyl)-1-nitrosourea Decomposition". . p. 1245 - 1247. Retrieved 1980.
• 4、 Rezsnyak, Chad E.,Autschbach, Jochen,Atwood, Jim D.,Moncho, Salvador. "Reactions of gold(III) complexes with alkenes in aqueous media: Generation of bis-(β-hydroxyalkyl)gold(III) complexes". . p. 1153 - 1165. Retrieved 2013.
• 5、 Harada, Kazuo,Yasui, Keiko. "Decomposition of ethylene, a flower-senescence hormone, with electrolyzed anode water.". . p. 790 - 796. Retrieved 2003.
• 6、 Chiang, Y.,Kresge, A. J.,Do, S. Van,Weeks, D. P.. "Catalysis by Undissociated H3PO4 in Aqueous H2PO4-/HPO42- Buffer Solutions: Dependence on The Magnitude of the Broensted Exponent". . p. 4035 - 4037. Retrieved 1986.
• 7、 Soerensen, Poul E.,Jencks, William P.. "Acid- and Base-Catalysed Decomposition of Acetaldehyde Hydrate and Hemiacetals in Aqueous Solution". . p. 4675 - 4690. Retrieved 1987.
• 8、 Yoshida,Yano. "Kinetic study of aqueous decompositions of N-(2-haloethyl)N'- cyclohexyl-N-nitrosoureas. Effect of haloethyl group on the preference in decomposition pathways". . p. 1557 - 1558. Retrieved 1983.
• 9、 Domask,Kobe. "". . p. 680 - 689. Retrieved 1954.
• 10、 Vijaya Durga,Balamurali Krishna,Baby Ramana,Santha Kumari,Vijay,Hari Babu. "BiCl3: A versatile catalyst for the tetrahydropyranylation and depyranylation of 1°,2°,3°, allylic, benzylic alcohols, and symmetric diols". . p. 1030 - 1034. Retrieved 2017.