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2-Chloroethanol

Base Information Edit
  • Chemical Name:2-Chloroethanol
  • CAS No.:107-07-3
  • Deprecated CAS:1867-09-0,1253945-55-9,1253945-55-9
  • Molecular Formula:C2H5 Cl O
  • Molecular Weight:80.5141
  • Hs Code.:29333999
  • European Community (EC) Number:203-459-7
  • ICSC Number:0236
  • NSC Number:122289
  • UN Number:1135
  • UNII:753N66IHAN
  • DSSTox Substance ID:DTXSID1021877
  • Nikkaji Number:J4.050I
  • Wikipedia:2-Chloroethanol
  • Wikidata:Q209354
  • NCI Thesaurus Code:C122479
  • Metabolomics Workbench ID:51618
  • ChEMBL ID:CHEMBL191244
  • Mol file:107-07-3.mol
2-Chloroethanol

Synonyms:2 Chlorethanol;2 Chloroethyl Alcohol;2-Chlorethanol;2-Chloroethyl Alcohol;Alcohol, 2-Chloroethyl;Chlorohydrin, Ethylene;Ethylene Chlorohydrin;Ethylenechlorhydrin

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 2-Chloroethanol Edit
Chemical Property:
  • Appearance/Colour:clear, colorless liquid. 
  • Vapor Pressure:4.79mmHg at 25°C 
  • Melting Point:-63 ºC 
  • Refractive Index:n20/D 1.441(lit.)  
  • Boiling Point:129 ºC 
  • Flash Point:55 ºC 
  • PSA:20.23000 
  • Density:1.201 
  • LogP:0.21750 
  • Water Solubility.:MISCIBLE 
  • XLogP3:-0.1
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:1
  • Rotatable Bond Count:1
  • Exact Mass:80.0028925
  • Heavy Atom Count:4
  • Complexity:10
  • Transport DOT Label:Poison Inhalation Hazard Flammable Liquid
Purity/Quality:
Safty Information:
  • Pictogram(s):  
  • Hazard Codes: T+:Very toxic;
     
  • Statements: R26/27/28:; 
  • Safety Statements: S28A:; S45:; S7/9:; 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Toxic Gases & Vapors -> Other Toxic Gases & Vapors
  • Canonical SMILES:C(CCl)O
  • Inhalation Risk:A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
  • Effects of Short Term Exposure:The substance is severely irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system, cardiovascular system, kidneys and liver. This may result in cardiac disorders, low blood pressure, kidney impairment, liver impairment and respiratory failure. Exposure could cause death.
Technology Process of 2-Chloroethanol

There total 153 articles about 2-Chloroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
iron(III) chloride; In carbon disulfide; for 40h; Ambient temperature;
Guidance literature:
With phosphate buffer; sodium chloride; at 70 ℃; pH=7.0; Kinetics;
DOI:10.1021/tx950155y
Refernces Edit

Syntheses of a linear pentadentate ligand and its zinc(II) complex and its promoted hydrolysis of 4-nitrophenyl acetate

10.1081/SIM-100002039

The research focuses on the synthesis and characterization of a linear pentadentate ligand, N-(2-hydroxyethyl)-N′′-(2-hydroxybenzyl)-diethylenetriamine (HL), and its zinc(II) complex. The study investigates the promoted hydrolysis of 4-nitrophenyl acetate (NA) by the zinc(II) complex. The ligand and its complex were synthesized using reagents like 2-chloroethanol, diethylenetriamine, and salicylaldehyde, and characterized using IR spectra, 1H NMR spectra, and elemental analyses. The protonation constants of HL and the stability constants of its Zn(II) complexation were determined through pH potentiometric titration at 25°C and I = 0.1 mol/L KNO3. The kinetics of NA hydrolysis catalyzed by the complex were studied spectrophotometrically at 25°C and I = 0.1 mol/L KNO3 in a CH3CN solvent, with the second-order rate constants (kc) for NA hydrolysis being obtained. The experiments involved the preparation of the ligand and its complex, pH titration to determine protonation and complexation equilibria, and kinetic studies to measure the rate of NA hydrolysis catalyzed by the complex.

β-Phenylselenoethanol, an efficient reagent for the one-pot synthesis of aryl vinyl ethers

10.3184/030823408X360355

The research describes a novel and efficient method for the one-pot synthesis of aryl vinyl ethers using β-phenylselenoethanol as a reagent. The purpose of the study was to develop a more experimentally simple and efficient methodology for the preparation of aryl vinyl ethers, which are key intermediates in various synthetic applications and polymeric materials. The researchers achieved this through a two-step process involving the Mitsunobu reaction of β-phenylselenoethanol with phenols, followed by oxidation-elimination with 30% hydrogen peroxide. The method concluded with good yields (85–90%) and had the advantages of mild reaction conditions and convenient manipulation. Key chemicals used in the process included β-phenylselenoethanol, phenols, diphenyl diselenide, sodium hydride, HMPA, 2-chloroethanol, and various phenolic substrates with different substituents. The study also reported the recovery of diphenyl diselenide in a 60% yield through the addition of hydrazine monohydrate to the aqueous extract containing benzeneseleninic acid.