L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl-

Base Information

• Chemical Name: L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl-
• CAS No.: 392715-25-2
• Molecular Formula: C17H21N5O6S
• Molecular Weight: 423.45
• Mol file: 392715-25-2.mol

Synonyms:

Chemical Property of L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl-

There total 1 articles about L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Tosyl isocyanate (4083-64-1) + Carnosine (305-84-0) → 4-toluenesulfonylureido-carnosine (392715-25-2)

Guidance literature:

at 4 ℃;

DOI:10.1016/S0928-0987(00)00122-6

Reference yield:

sulfanilylcyanamide (116-47-2) + 4-toluenesulfonylureido-carnosine (392715-25-2) → C24H26N8O7S2 (1027583-08-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 4 ℃; for 16h;

DOI:10.1021/jm9903693

Reference yield:

4-toluenesulfonylureido-carnosine (392715-25-2) → C24H29N9O7S2

Guidance literature:

Multi-step reaction with 3 steps

1: EDCI*HCl; Et₃N / acetonitrile / 16 h / 4 °C

2: HCl(g) / dioxane / 96 h / 4 °C

3: NH₃ / methanol; ethanol / 4 h / 60 °C

With hydrogenchloride; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; ethanol; acetonitrile; 1: Condensation / 2: Addition / 3: Substitution;

DOI:10.1021/jm9903693

upstream raw materials:

Tosyl isocyanate

Carnosine

Downstream raw materials:

C₂₄H₂₆N₈O₇S₂

C₂₅H₃₀N₈O₈S₂

Refernces

• 1、 Supuran, Claudiu T.,Scozzafava, Andrea,Briganti, Fabrizio,Clare, Brian W.. "Protease inhibitors: Synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O- methylsulfonylisourea moieties at P1". . p. 1793 - 1806. Retrieved 2007/10/03.