N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide

Base Information

Chemical Name:N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide
CAS No.:395-99-3
Molecular Formula:C9H7F3N2O3
Molecular Weight:248.161
Hs Code.:
DSSTox Substance ID:DTXSID30468311

Synonyms:N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide;395-99-3;DTXSID30468311;OUBDJIKZZHLUBF-UHFFFAOYSA-N

Suppliers and Price of N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:248.04087658
Heavy Atom Count:17
Complexity:314

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=C(C=CC(=C1)C(F)(F)F)[N+](=O)[O-]

Technology Process of N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide

There total 8 articles about N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 402-14-2
2-nitro-5-(trifluoromethyl)aniline

: 108-24-7
acetic anhydride

: 395-99-3
N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide

Guidance literature:: With sulfuric acid; at 80 ℃; for 1h;
DOI:10.1016/j.ejmech.2005.09.001

Reference yield: 60.0%

: 351-36-0
N-acetyl-3-trifluoromethylbenzenamine

: 395-99-3
N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide

Guidance literature:: With Iron(III) nitrate nonahydrate; N-hydroxyphthalimide; In 1,2-dichloro-ethane; at 50 ℃; for 10h; regioselective reaction;
DOI:10.1039/c8ob00841h

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 395-99-3
N-[2-nitro-5-(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / potassium nitrate / 0 - 25 °C

2: 96 percent / potassium carbonate / ethanol; H₂O / 3 h / 50 °C

3: 97 percent / H₂SO₄ / 1 h / 80 °C

With sulfuric acid; potassium carbonate; potassium nitrate; In ethanol; water;
DOI:10.1016/j.ejmech.2005.09.001