Nitric Acid

Base Information

• Chemical Name: Nitric Acid
• CAS No.: 7697-37-2
• Deprecated CAS: 218625-70-8,78989-43-2,802862-59-5,1053657-18-3,1173016-70-0,1316336-39-6,1431325-80-2,2108694-78-4,807260-90-8,2195414-73-2,1053657-18-3,78989-43-2
• Molecular Formula: HNO3
• Molecular Weight: 64.0061
• Hs Code.: 2808.00
• European Community (EC) Number: 231-714-2,682-472-3
• ICSC Number: 0183
• NSC Number: 177677
• UN Number: 2032,2031
• UNII: 411VRN1TV4
• DSSTox Substance ID: DTXSID5029685
• Wikipedia: Nitric acid,Nitric_acid
• Wikidata: Q83320,Q10866256
• NCI Thesaurus Code: C28202
• RXCUI: 1311391
• ChEMBL ID: CHEMBL1352
• Mol file: 7697-37-2.mol

Synonyms:Acid, Nitric;Nitric Acid

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Chemical Property of Nitric Acid

Chemical Property:

• Appearance/Colour: Colourless clear liquid
• Melting Point: - 42 °C
• Boiling Point: 83 °C at 760 mmHg
• Flash Point: 120.5°C
• PSA: 66.05000
• Density: 1.623 g/cm³
• LogP: 0.17550
• Water Solubility.: >100 g/100 mL (20℃)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 62.995642894
• Heavy Atom Count: 4
• Complexity: 24.8
• Transport DOT Label: Corrosive Oxidizer Poison Inhalation Hazard

Purity/Quality:

Safty Information:

• Pictogram(s): C,O
• Hazard Codes: O:Oxidizing agent
• Statements: R8:; R35:
• Safety Statements: S23:; S26:; S36:; S45:

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Acids, Inorganic
• Canonical SMILES: [N+](=O)(O)[O-]
• Inhalation Risk: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause asthma-like reactions (RADS). Exposure could cause asphyxiation due to swelling in the throat. Inhalation of high concentrations may cause pneumonitis and lung oedema.
• Effects of Long Term Exposure: Repeated or prolonged inhalation may cause effects on the teeth. This may result in tooth erosion. The substance may have effects on the upper respiratory tract and lungs. This may result in chronic inflammation of the respiratory tract and reduced lung function . Mists of this strong inorganic acid are carcinogenic to humans.

Technology Process of Nitric Acid

There total 520 articles about Nitric Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

water (7732-18-5) + 1-(2-bromo-2-nitrovinyl)-4-nitrobenzene (7559-38-8) → bromonitromethane (563-70-2) + hydrogen bromide (10035-10-6,12258-64-9) + nitric acid (7697-37-2,78989-43-2) + cis-nitrous acid (7782-77-6)

Guidance literature:

Reference yield:

β-bromo-2,β-dinitro-styrene + water (7732-18-5) → bromonitromethane (563-70-2) + hydrogen bromide (10035-10-6,12258-64-9) + nitric acid (7697-37-2,78989-43-2) + cis-nitrous acid (7782-77-6)

Guidance literature:

Reference yield:

water (7732-18-5) + bromo-dimethyl sulfonium ; nitrate → hydrogen bromide (10035-10-6,12258-64-9) + nitric acid (7697-37-2,78989-43-2) + dimethyl sulfoxide (67-68-5,8070-53-9)

Guidance literature:

DOI:10.1002/zaac.19572900103

upstream raw materials:

2-nitroamino-1,3-diazacyclopent-2-ene

nitro-tetrahydropyrimidin-2-ylidene-amine

sulfuric acid

acetic acid

Downstream raw materials:

1H-imidazole

5-nitrobarbituric acid

8-azaxanthine

2-Iodothiophene

Refernces

5-Methyl-2-furylglyoxal, 5-methyl-4-nitro-2-furylglyoxal, and their derivatives. Nitration of 2-(5-methyl-2-furyl)quinoxaline

10.1023/A:1020669301326

The study primarily investigates the oxidation of 2-acetyl-5-methyl-4-R-furans (R = H, NO2) using selenious acid, resulting in derivatives with substitutions at the C=O groups of the corresponding glyoxals. Key chemicals include 5-R-2-Furylglyoxals (R = H, NO2), 2-(5-methyl-2-furyl)quinoxaline, and nitric acid for nitration purposes. The study's purpose is to explore the reactivity of methyl groups in heterocyclic compounds and ketones towards oxidation by selenious acid and to understand the nitration process of 2-(5-methyl-2-furyl)quinoxaline, which occurs at the C(4') position. The research also delves into the oxidative splitting of the β-nitrofuryl group at specific carbon bonds.

Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/Ref-1)

10.1021/jm9014857

The research focuses on the design and synthesis of novel quinone inhibitors targeting the redox function of the multifunctional enzyme apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1), which plays a crucial role in DNA repair and transcription regulation. The study involved synthesizing a series of benzoquinone and naphthoquinone analogues, particularly based on the known inhibitor E3330, to evaluate their inhibitory effects on Ape1's redox activity and tumor cell growth. Key reactants included various substituted phenols and phosphonates, with reactions facilitated by methods such as Emmons condensation and oxidation using reagents like nitric acid and ceric ammonium nitrate. Analyses included electrophoretic mobility shift assays (EMSA) to measure redox inhibition and MTS assays to assess cell growth inhibition, providing insights into structure-activity relationships and the potential therapeutic applications of these compounds.