Phosphoric acid, 2,6-dimethylphenyl diethyl ester

Base Information

• Chemical Name: Phosphoric acid, 2,6-dimethylphenyl diethyl ester
• CAS No.: 39604-15-4
• Molecular Formula: C12H19O4P
• Molecular Weight: 258.254
• Mol file: 39604-15-4.mol

Synonyms:

Chemical Property of Phosphoric acid, 2,6-dimethylphenyl diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid, 2,6-dimethylphenyl diethyl ester

There total 12 articles about Phosphoric acid, 2,6-dimethylphenyl diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

n-butyllithium (109-72-8,29786-93-4) + 2,6-dimethylphenyl 2-phenylbutanoate (1427179-44-9) + diethyl chlorophosphate (814-49-3) → (Z)-diethyl (3-phenyloct-3-en-4-yl)phosphate (1427179-52-9) + 2,6-dimethylphenyl diethyl phosphate (39604-15-4)

Guidance literature:

2,6-dimethylphenyl 2-phenylbutanoate; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h; Inert atmosphere;

n-butyllithium; In diethyl ether; hexane; at -78 - -20 ℃; Inert atmosphere;

diethyl chlorophosphate; In diethyl ether; hexane; at -20 - 22 ℃; for 15h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol400392r

Reference yield: 84.0%

n-butyllithium (109-72-8,29786-93-4) + 2,6-dimethylphenyl 2-(o-tolyl)propanoate (1427179-48-3) + diethyl chlorophosphate (814-49-3) → (Z)-diethyl (2-(o-tolyl)hept-2-en-3-yl)phosphate (1427179-65-4) + 2,6-dimethylphenyl diethyl phosphate (39604-15-4)

Guidance literature:

2,6-dimethylphenyl 2-(o-tolyl)propanoate; With tert.-butyl lithium; In diethyl ether; hexane; pentane; at -78 ℃; for 1h; Inert atmosphere;

n-butyllithium; In diethyl ether; hexane; pentane; at -78 - -20 ℃; Inert atmosphere;

diethyl chlorophosphate; In diethyl ether; hexane; pentane; at -20 - 22 ℃; for 15h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol400392r

Reference yield: 80.0%

2.6-dimethylphenol (576-26-1,25134-01-4) + triethyl phosphate (78-40-0) → 2,6-dimethylphenyl diethyl phosphate (39604-15-4)

Guidance literature:

triethyl phosphate; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 0.166667h;

2.6-dimethylphenol; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.8b02073

upstream raw materials:

diethyl phosphite potassium salt

2,6-dimethylphenyl trifluoromethanesulphonate

trimethyl-2,4,6 phenate de potassium

2.6-dimethylphenol

Downstream raw materials:

2,6-dimethylaniline

6-methyl-2-phosphonomethylphenol

Refernces

• 1、 You, Wei,Li, Yan,Brown, M. Kevin. "Stereoselective synthesis of all-carbon tetrasubstituted alkenes from in situ generated ketenes and organometallic reagents". supporting information. p. 1610 - 1613. Retrieved 2013/06/26.
• 2、 Creary, Xavier,Benage, Brigitte,Hilton, Kathryn. "Reaction of Triflates with Potassium Diethyl Phosphite. Formation of Phosphate Esters". . p. 2887 - 2891. Retrieved 2007/10/02.