78-40-0 Usage
Description
Triethyl phosphate is an organic compound with the chemical formula (C2H5O)3PO, characterized by its phosphorus atom bonded to three ethoxy groups. It is a colorless, oily liquid with a faint, ethereal odor. Triethyl phosphate is known for its flame retardant properties, as well as its ability to act as a viscosity reducer, catalyst, solvent, and intermediate in various chemical reactions.
Uses
Used in Plastics and Foam Insulation Industry:
Triethyl phosphate is used as a flame retardant for enhancing the fire resistance of materials in the manufacture of polyisocyanurate (PIR) and polyurethane (PUR) foam insulation. Its incorporation into these materials helps to slow down the spread of flames and reduce the heat release rate during a fire, thereby improving the safety of the final product.
Used in Plastic Resins:
In the plastics industry, Triethyl phosphate is utilized as a viscosity reducer in plastic resins. Its addition to the resin formulation helps to lower the viscosity, making it easier to process and handle during manufacturing. This results in improved flow properties and better overall performance of the final plastic product.
Used in Pesticide Production:
Triethyl phosphate serves as a catalyst, solvent, or intermediate in the production of pesticides. Its involvement in the synthesis process contributes to the development of effective and efficient pesticide formulations that protect crops from pests and diseases, ensuring higher yields and better quality produce.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Triethyl phosphate is employed as a catalyst, solvent, or intermediate in the synthesis of various pharmaceutical compounds. Its use in these processes aids in the development of new drugs and medications, contributing to advancements in healthcare and medicine.
Used in Lacquer Production:
Triethyl phosphate is used as a solvent in the production of lacquers, which are clear or pigmented coatings applied to various surfaces for protection and aesthetic purposes. Its ability to dissolve resins and other components of lacquer formulations makes it a valuable ingredient in the creation of high-quality lacquer products.
Used as an Ethylating Agent:
Triethyl phosphate functions as an ethylating agent in chemical reactions, where it donates ethyl groups to other molecules. This property is useful in the synthesis of various organic compounds, including polyesters, which are used as insecticides.
Production Methods
Triethyl phosphate is manufactured from diethyl ether and phosphorus pentoxide via a metaphosphate intermediate.Prepared by the reaction of tetraethyl hypophosphate with ethanol in the presence of aluminum ethoxide or by treating triethyl phosphate with diethyl hydrogen phosphate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 25, p. 1000, 1960 DOI: 10.1021/jo01076a035
Air & Water Reactions
Slowly dissolves in water with slight decomposition .
Reactivity Profile
Organophosphates, such as Triethyl phosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health Hazard
May be harmful by inhalation, ingestion or absorption. May cause irritation.
Fire Hazard
Special Hazards of Combustion Products: May produce hazardous decomposition products such as carbon dioxide, carbon monoxide and oxides of phosphorus.
Flammability and Explosibility
Nonflammable
Safety Profile
Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Experimental reproductive effects. Mutation data reported. Causes cholinesterase inhibition, but to a lesser extent than parathion. May be expected to cause nerve injury similar to that of other phosphate esters. Triethyl phosphate is stable under normal conditions of use. Avoid contact with strong bases and oxidizing agents. Triethyl phosphate is combustible at high temperatures. Heating to decomposition may release carbon dioxide, carbon monoxide, phosphorus oxides and other potentially toxic fumes or gases. Avoid heat, open flames and other potential sources of ignition.
Check Digit Verification of cas no
The CAS Registry Mumber 78-40-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 78-40:
(4*7)+(3*8)+(2*4)+(1*0)=60
60 % 10 = 0
So 78-40-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H15O4P/c1-4-8-11(7,9-5-2)10-6-3/h4-6H2,1-3H3
78-40-0Relevant articles and documents
Photochemical Radical C–H Halogenation of Benzyl N-Methyliminodiacetyl (MIDA) Boronates: Synthesis of α-Functionalized Alkyl Boronates
Yang, Ling,Tan, Dong-Hang,Fan, Wen-Xin,Liu, Xu-Ge,Wu, Jia-Qiang,Huang, Zhi-Shu,Li, Qingjiang,Wang, Honggen
supporting information, p. 3454 - 3458 (2020/12/17)
α-Haloboronates are useful organic synthons that can be converted to a diverse array of α-substituted alkyl borons. Methods to α-haloboronates are limiting and often suffer from harsh reaction conditions. Reported herein is a photochemical radical C-H halogenation of benzyl N-methyliminodiacetyl (MIDA) boronates. Fluorination, chlorination, and bromination reactions were effective by using this protocol. Upon reaction with different nucleophiles, the C?Br bond in the brominated product could be readily transformed to a series of C?C, C?O, C?N, C?S, C?P, and C?I bonds, some of which are difficult to forge with α-halo sp2-B boronate esters. An activation effect of B(MIDA) moiety was found.
Preparation method of phosphate ester compound
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Paragraph 0042-0055, (2021/08/25)
The invention discloses a preparation method of a phosphate ester compound, belonging to the field of phosphate ester compounds. The preparation method of the phosphate ester compound comprises the following steps: putting sodium diethyl phosphate into a reactor as a raw material, then putting a catalyst, a reaction solvent and an alkylating reagent into the reactor, conducting stirring, heating and reacting for a period of time, and finally, carrying out post-treatment on reaction liquid to obtain triethyl phosphate. According to the method, sodium diethyl phosphate is taken as the raw material, so the waste is treated by the waste, resources are recycled, and pollution is reduced; chloroethane is taken as the alkylating reagent; and thus, a novel, efficient, environment-friendly and economical method for synthesizing a triethyl phosphate compound is provided.
Some Transformations of Mono-and Dichloro(diethoxyphosphoryl)acetaldehydes
Allakhverdieva, G. E.,Ismailov, V. M.,Mamedov, I. A.,Sadykhova, N. D.,Yusubov, N. N.
, p. 89 - 92 (2020/04/09)
Addition of ethanol and diethyl phosphonate to the carbonyl group of 2,2-dichloro-2-(diethoxyphosphoryl)-acetaldehyde has been studied, and the corresponding α-chloro ether, acetal, and phosphorylated metrifonate have been obtained. α,α-Dichloro-α-phospho
