Aids093389

Base Information

• Chemical Name: Aids093389
• CAS No.: 141396-11-4
• Molecular Formula: C₄₂H₅₁N₄O₈P
• Molecular Weight: 770.863
• Mol file: 141396-11-4.mol

Synonyms:

Chemical Property of Aids093389

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1040.9°Cat760mmHg
• Flash Point: 583.3°C
• PSA: 181.97000
• Density: 1.225g/cm³
• LogP: 8.09240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Aids093389

There total 3 articles about Aids093389 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) + Bis-((S)-1-amino-2-phenyl-ethyl)-phosphinic acid → Bis-[(S)-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2-phenyl-ethyl]-phosphinic acid (141396-11-4) + Bis-[(R)-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2-phenyl-ethyl]-phosphinic acid (141396-10-3)

Guidance literature:

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

Reference yield:

benzyl bromide (100-39-0) → Bis-[(S)-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2-phenyl-ethyl]-phosphinic acid (141396-11-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) -78 deg C, 2.) -78 deg C, 24 h

2: 95 percent / 30percent HBr / acetic acid

3: O--N,N,N',N'-tetramethyluronium-tetrafluoroborate / dimethylformamide / 2 h / 25 °C

With n-butyllithium; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; hydrogen bromide; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

Bis-[(R)-1-(benzhydrylidene-amino)-2-phenyl-ethyl]-phosphinic acid ethyl ester → Bis-[(S)-1-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2-phenyl-ethyl]-phosphinic acid (141396-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 30percent HBr / acetic acid

2: O--N,N,N',N'-tetramethyluronium-tetrafluoroborate / dimethylformamide / 2 h / 25 °C

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; hydrogen bromide; In acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

(S)-N-(benzyloxycarbonyl)valine

benzyl bromide

Refernces